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Biologists at the Simons Foundation’s Flatiron Institute and their colleagues strive to better understand remarkable living systems by bringing biology and mathematics into closer dialogue. -
… cryo-EM data. To create the most useful tools, Flatiron researchers brought together an interdisciplinary cohort of investigators to provide input. Cossio and computational biophysicist Sonya Hanson … -
Kabacaoglu, a former research fellow at the Simons Foundation’s Flatiron Institute, is now an assistant professor in the Department of Computer Science at Durham University in England … -
Collaborations during Morton’s time as an associate research scientist at the Simons Foundation’s Flatiron Institute inspired his new startup. -
Flatiron Institute Senior Research Scientist Pilar Cossio builds tools to analyze experimental measurements and reveal how environmental changes alter the behavior of RNA molecules. -
Flatiron Institute scientists and experimental collaborators tested a theory that treats chromosome-separating cellular structures called spindles as active liquid crystals. They found that the theory largely succeeds … -
Bacteria tails rotate counterclockwise to propel the bacteria through liquid environments and clockwise to change direction. Previous research has suggested that the direction of the spin depends on … -
Researchers at the Flatiron Institute’s Center for Computational Biology and their collaborators from Princeton University and the Max Planck Institute in Dresden, Germany, use experimental and computational … -
An analysis of more than 5,000 individuals with autism reveals four distinct groups that link autism-related traits with underlying genetics. The work could open the door … -
A Flatiron Institute scientist has developed the first analytical model for predicting how bacteria spread in environments filled with obstacles. This model will help inform strategies for curbing … -
Through simulations and modeling of bacterial colonies, researchers at the Flatiron Institute and collaborators have discovered how dividing cells adapt to crowded environments by slowing their growth, informing … -
CRISPR promises to be a game changer in the development of treatments for genetic diseases, but sometimes the technology slices DNA where it’s not supposed to. A … -
New research led by Flatiron Institute researchers reveals the source of the mysterious swirling flows in some of nature’s largest cells. -
Last month, Flatiron Institute postdoc Miro Astore received the Young Biophysicist Award at the 47th Annual Conference of the Australian Society for Biophysics. The award was established in … -
For the first time, the five Flatiron Institute research centers (astrophysics, biology, mathematics, neuroscience and quantum physics), as well as its Scientific Computing Core and the Foundation Models … -
By studying the changing geometry of cell nuclei in fruit flies, scientists have gained a better understanding of the dynamics that shape the part of our cells that … -
Flatiron Institute Research Fellow Brato Chakrabarti studies how tiny objects in our bodies work collectively to make big waves. -
In using AI-powered tools to map proteins in the human gut microbiome, researchers have challenged the traditional view of the relationship between protein sequence, structure and function. -
In her studies of insects, Flatiron Institute Research Fellow Tatyana Gavrilchenko is gaining new insights into the complexities of the vasculature system — work that could inform efforts at … -
By harnessing both experimental and computational methods, researchers have identified a significant role for randomness in disease manifestation. -
By monitoring the body’s molecular response to a viral attack, the new method developed by Flatiron Institute researchers and their colleagues can diagnose even asymptomatic patients with … -
The Alfred P. Sloan Foundation has awarded its prestigious research fellowship to four past and present Simons Foundation researchers. This year’s 125 fellowship recipients “represent the most … -
A new facility at the Flatiron Institute’s Center for Computational Biology (CCB) bridges the gap between experimental and theoretical biology, allowing researchers to take big steps toward … -
The nucleus of a cell may only be one-thousandth of a centimeter in diameter, but that doesn’t stop biophysicist Alex Rautu from seeing the big picture. -
Built from one of the world’s largest collections of epigenetic data, the newly developed model Sei predicts how DNA sequence variation alters gene expression, advancing our understanding … -
Developmental biologist Jasmin Imran Alsous knows that it takes a village to raise an egg cell. At the Flatiron Institute, she and her collaborators are working together to … -
At the Flatiron Institute, Christopher Park studies how mutations in RNA might play a role in neuropsychiatric conditions like autism, schizophrenia and ADHD. -
… New York University Courant Institute -
By building a biophysical model that incorporates real-world biological complexity, scientists discover important links between the nanometer-sized motors that power a cell’s cilia and the … -
A new study reveals that communication between cells encasing the developing fruit fly egg chamber induces unequal cell division, shedding light on a fundamental biological process. -
By stitching together an unprecedented diversity of data, a new software platform has enabled scientists to robustly predict what proteins do. -
… the sheet of follicle cells that surrounds it. “These two tissue types need to grow together, and later, the follicle cells that stay over the nurse cells … -
Underlying all biological processes are molecules and their interactions with each other. However, our ability to understand how these molecules function over biologically relevant scales remains very limited … -
The swirling currents occur when the rodlike structures that extend inward from the cells’ membranes bend together like wheat stalks caught in a strong breeze, report researchers at … -
In new research, scientists take a biophysical approach to deciphering the cell’s mysteries. -
This powerful, dynamic software system is changing how scientists sift through the recent deluge of human genomic data — and deepening our knowledge of human biology, health and disease. -
Vulnerable kidney cells undergo similar cellular processes during diabetic kidney disease and COVID-19 infection, potentially explaining why the two illnesses together are so deadly. -
The suite of software tools collectively known as Rosetta is defined not only by what it does, but also by a community of scientists who are changing how … -
… something similar about the fiery bodies racing across the sky until some bold thinkers cracked the patterns. As a reproducible and evolvable system subject to cutting-edge … -
Neurons that regularly remodel are more prone to the dysfunctions linked to the disease’s onset, a new experimental and computational study finds. -
Genetic dark matter makes up 98 percent of our genomes, yet scientists are still figuring out how it works. -
Solving the mysteries of the brain requires reverse engineering the rules and patterns that control it. -
The institute has grown from a beautiful proposal into a bustling hub for computational science in astrophysics, biology, mathematics and quantum physics. -
Cerebral fascinations: We asked our neuroscientists why they find the brain beautiful. -
The finely tuned collection of bacteria, archaea and fungi collectively known as the microbiome hold an exquisite power that we are only beginning to recognize. -
A model system exploring ATP synthase reveals that rotation, repulsion and flow can crystallize proteins. It may explain a biophysical mystery in mitochondrial membranes.
