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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Communication among sensorimotor cortices: Where state space meets biology

    Funded Work
    Movement is the primary way animals interact with the world.
  2. Investigating symbol-like reasoning in the brain: Neural mechanisms of compositional action planning

    Funded Work
    Humans and other animals can rapidly solve new problems — such as imitating a dance from a single observation — by adaptively combining components from prior knowledge to generate new …
  3. Theory-driven approaches to identify minimal circuits for susceptibility and resilience

    Funded Work
    Individuals vary widely in the types of behavioral transitions they undergo in response to adverse environmental conditions.
  4. Brainwide dynamics of a social interaction

    Funded Work
    Communication is a fundamental aspect of life among animals, and yet we lack a comprehensive understanding of the underlying neural mechanisms.
  5. NetQuilt: A Powerful Computational Approach for Predicting Protein Function

    October 5, 2021
    By stitching together an unprecedented diversity of data, a new software platform has enabled scientists to robustly predict what proteins do.
  6. Perceptual Impairments and Altered Excitatory–Inhibitory Activity in Cntnap2 Knockout Mice

    September 30, 2021
    Bilal Haider and colleagues found that Cntnap2 knockout mice exhibited deficits in visual perception and that these were associated with diminished excitation and elevated inhibition in the visual …
  7. Fetal Responses to Maternal Infection May Help Explain Prevalence of Autism in Males

    September 30, 2021
    Jun Huh and colleagues found that maternal immune responses to infection may at least partially explain sex-specific differences in autism risk.
  8. Reading Genomes: The Key to Life and to Thwarting Death

    September 30, 2021
    … people show symptoms of COVID-19. ‍ Investing in the future If sequencing technology prepared us for the COVID-19 pandemic, that’s only because of the decades …
  9. 2021 SFARI Human Cognitive and Behavioral Science Awardees Announced

    September 29, 2021
    SFARI is pleased to announce that it intends to award 11 grants in response to the 2021 Human Cognitive and Behavioral Science request for applications.
  10. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    September 29, 2021
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  11. How Neuroscientists Are Adapting to the Ongoing Pandemic

    September 29, 2021
    Researchers are pivoting in clever ways, but they worry that the lack of spontaneous interactions is harming the next generation.
  12. Study Using SPARK Data Uncovers New Inherited Genetic Risks for Autism

    September 28, 2021
    A recent study has uncovered new ASD inherited genetic risk variants. Over of the 50 percent of the genetic data used in the study came from SPARK.
  13. Probing the Neural Circuits of Social Interactions in Monkeys

    September 28, 2021
    Michael Platt and colleagues found that monkeys create complex internal representations of social situations and uncovered neural circuitry supporting social cooperation.
  14. A Conversation With SFARI Consultant-in-Residence Gaspar Taroncher-Oldenburg

    September 28, 2021
    SFARI consultant-in-residence Gaspar Taroncher-Oldenburg discusses his work and collaboration with the Simons Foundation Flatiron Institute to study the microbiome and its potential implications for ASD …
  15. ASHG 2021 Virtual Meeting: Presentations by SFARI Investigators and Collaborators

    September 28, 2021
    A number of SFARI Investigators, collaborators and Simons Foundation scientists will present their latest research findings at the American Society of Human Genetics (ASHG) 2021 Virtual Meeting, which …
  16. Elliptic Curves: Simple Equations Still Shrouded in Mystery

    September 27, 2021
    For more than 2,000 years, number theorists have been trying to understand the properties of solutions to polynomial equations. In his research, Simons Junior Fellow Michele Fornea …
  17. SFARI Spring 2021 Science Meeting Discusses Key Issues in Autism Research, Treatments and Genetic Risk

    September 23, 2021
    SFARI held a virtual version of its spring science meeting in a series of four webinars in April and May 2021. The webinars were organized around themes of …
  18. Computational Chemist Erik Thiede Named a Finalist for Blavatnik Regional Award for Young Scientists

    September 21, 2021
    The Blavatnik Family Foundation and the New York Academy of Sciences have named computational chemist Erik Thiede as a finalist for the 2021 Blavatnik Regional Award for Young …
  19. New Zebrafish Lines Added to SFARI Resources

    September 20, 2021
    Zebrafish lines for autism risk genes DYNC1H1 and MEF2C have been recently added to SFARI resources to study autism spectrum disorder.
  20. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    September 15, 2021
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
  21. Super Agers and Centenarians: The Search for Protective Factors

    September 14, 2021
    Longitudinal studies of the oldest old could reveal how some people’s brains resist the ravages of time.
  22. Inaugural 2021 SCGB Undergraduate Research Fellowship Awardees Announced

    September 9, 2021
    In an effort to enhance diversity in neuroscience, a new program from the Simons Collaboration on the Global Brain (SCGB) pairs undergrads with research mentors.
  23. Building Computer Models That See Everything

    August 30, 2021
    Simons Junior Fellow and computational neuroscientist Kathryn Bonnen uses advanced modeling and experimental techniques to help us understand what happens inside our minds as we perceive the world …
  24. SFARI Workshop Explores Sleep Challenges in Autism Spectrum Disorder

    August 27, 2021
    On June 25 and 28, 2021, SFARI hosted a workshop to discuss sleep challenges in autism and learn more about ways to improve sleep quality in individuals with …
  25. A Conversation With SFARI BTI and SEED Awardee J. Elliott Robinson

    August 26, 2021
    J. Elliott Robinson talks about his lab’s work on the neural circuits involved in neurofibromatosis type 1 and developing gene therapy treatments for the condition, and how …
  26. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    August 26, 2021
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  27. Excessive Dendritic Spine Clusters in MECP2 Duplication Syndrome Mouse Model

    August 25, 2021
    Stelios Smirnakis and Huda Zoghbi observed an increase in the formation and stabilization of dendritic spine clusters in the cortex of MECP2 duplication syndrome mice.
  28. Large Cohorts Aid in Genotype-Phenotype Analyses

    August 25, 2021
    Evan Eichler and colleagues used targeted sequencing in large neurodevelopmental cohorts, including SPARK, to identify new risk genes and relate genotype to phenotypic presentation.
  29. Sensory Habituation Is Reduced in Autism

    August 25, 2021
    Pawan Sinha and colleagues found that sensory habituation is reduced in autism, and furthermore, that this reduction correlates with behavioral assessments of social communication and sensory difficulties.
  30. SFARI Announces the Awardees of the Supplemental Funding for Studies of Maternal COVID-19 as a Potential Risk for Autism

    August 25, 2021
    SFARI is pleased to announce that it intends to fund four grants in response to the Maternal COVID-19 as a Potential Risk for Autism: Supplemental Funding for …
  31. Scoring the Brain: How Benchmark Datasets and Other Tools Are Solving Key Challenges in Neuroscience

    August 25, 2021
    With standardized datasets, community-building challenges and simplified software bundles, research initiatives strive to bring uniformity to analysis in neuroscience.
  32. Seeing Is Believing: Exposing the “Invisible Monster”

    August 25, 2021
    … spike proteins; and, in a new wrinkle, the sugary invisibility cloaks worn by the spikes to conceal them from the immune system. Discovering those sugar cloaks was …
  33. Critical windows and reversibility of autism associated with mutations in chromatin remodelers

    Funded Work
    Neurodevelopmental conditions, such as autism spectrum disorder (ASD) and intellectual disability, affect more than three percent of children worldwide, yet in the majority of cases, therapeutic options and …
  34. SFARI 2021 Bridge to Independence Fellows Announced

    August 19, 2021
    SFARI is pleased to announce that it has selected six fellows in response to the 2021 Bridge to Independence Award request for applications.
  35. Cracking a Mystery of Massive Black Holes and Quasars With Supercomputer Simulations

    August 17, 2021
    … central accreting supermassive black hole. Anglés-Alcázar et al. Astrophysical Journal 2021 “This is the first time that we have been able to create a simulation that …
  36. Nearby Star-Forming Region Yields Clues to the Formation of Our Solar System

    August 16, 2021
    The Ophiuchus star-forming complex offers an analog for the formation of the solar system, including the sources of elements found in primitive meteorites.
  37. Black Holes Flicker When They Eat, Revealing Their Size

    August 12, 2021
    … Astronomers worldwide are waiting for the official kickoff of an era of massive surveys that monitor the dynamic and variable sky. Starting in late 2023, the Vera …
  38. What’s Next for Science Sandbox

    August 11, 2021
    Ivvet Modinou named director, Outreach, Education and Engagement; John Tracey named program director of Science Sandbox; and some hellos and goodbyes
  39. SPARK: Five Years Accelerating Autism Gene Discovery and Research

    August 9, 2021
    Since launching in 2016, SPARK has driven scientific discovery in autism, building a cohort of over 280,000 individuals, including more than 100,000 children and adults with …
  40. Autism BrainNet Tissue Requests Can Now Be Made Through SFARI Base

    July 29, 2021
    Researchers interested in requesting brain tissue from Autism BrainNet can now submit their applications through SFARI Base, SFARI’s clearinghouse for autism and autism-related research data and …
  41. 2020 SFARI Collaboration on Sex Differences in Autism Awardees Announced

    July 29, 2021
    SFARI is pleased to announce that it intends to fund five collaborative groups in response to the 2020 SFARI Collaboration on Sex Differences in Autism request for applications.
  42. Inaugural SCGB 2021 Bridge to Independence Fellows Announced

    July 29, 2021
    The Simons Collaboration on the Global Brain (SCGB) is pleased to announce its inaugural class of Bridge to Independence (BTI) fellows.
  43. Exponentially Important: The Scientific Origins of PCR

    July 28, 2021
    … of being internally quantitative, meaning that you can count the absolute number of molecules that were in the starting material. That’s probably the next 20 years …
  44. Karin Öberg’s Search for the Chemical Basis of Planet Formation

    July 28, 2021
    With new tools offering an unprecedented view of a planet’s molecular building blocks, astrochemists are working to pin down the recipe for a habitable world.
  45. Watch: When Galaxies Collide

    July 27, 2021
    Galaxy clusters are some of the largest known structures in the universe. Astrophysicist Chris Hayward explains what happens when galaxies within those clusters collide.
  46. Magnetic ‘Balding’ of Black Holes Saves General Relativity Prediction

    July 27, 2021
    Magnetic fields around black holes decay quickly, report researchers from the Flatiron Institute, Columbia University and Princeton University. This finding backs up the so-called ‘no-hair conjecture …
  47. Studies of Women’s Longevity Offer Clues to Cognitive Resilience for All

    July 26, 2021
    Across animal species and human cultures, females outlive males and appear less susceptible to cognitive decline with age. Scientists are exploring these sex-linked differences to identify interventions …
  48. Rare Inherited Variants in Previously Unsuspected Genes May Confer Significant Risk for Autism

    July 26, 2021
    New study in Nature Genetics uses SPARK database to investigate variants that are less damaging than de novo mutations, but contribute almost as much risk.
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