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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. MPS Announces New Scientific Advisory Board Members

    April 27, 2020
    … York City–based campus focused on graduate education that integrates technology, business, law and design in service of economic impact and societal good. Morrisett’s research focuses …
  2. Simons-Funded Researchers Elected as 2020 Fellows of the American Academy of Arts and Sciences

    April 27, 2020
    Seven researchers supported by the Simons Foundation and board member Margaret Hamburg are among the latest group of prominent artists, scholars, scientists and leaders elected as fellows of …
  3. Bang, Bounce or Something Else?

    April 22, 2020
    Time began at the Big Bang — or did it? Alternative ideas, including a universe that repeatedly reboots itself, suggest something came before the Big Bang.
  4. Practicing Neuroscience During a Pandemic

    April 20, 2020
    In the wake of massive lab shutdowns, systems and computational neuroscientists are figuring out how to continue their work without performing experiments.
  5. Yanbei Chen Examines Gravitational Waves To Test Relativity

    April 17, 2020
    Caltech’s Yanbei Chen describes how he uses data from LIGO and other instruments to probe relativity and the fundamentals of quantum mechanics.
  6. History of the Autism Mystery

    April 15, 2020
    Despite numerous breakthroughs into the causes of autism, many mysteries about the condition remain.
  7. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    April 14, 2020
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  8. Deciphering the Brain’s Algorithms

    April 9, 2020
    Solving the mysteries of the brain requires reverse engineering the rules and patterns that control it.
  9. Neural Coding: A Truly Cerebral Puzzle

    April 9, 2020
    Individual neurons and regions of the brain can encode surprisingly strange combinations of information.
  10. How Lucy Colwell Finds Never-Before-Seen Proteins

    April 9, 2020
    High-throughput DNA sequencing and other technologies help Lucy Colwell, a lecturer of chemistry at the University of Cambridge, design and discover entirely new kinds of proteins.
  11. Eric Kandel and the Joy of Studying the Mind

    April 3, 2020
    The Columbia University neuroscientist, who won a Nobel Prize for his work on memory, explains why the biology of the mind continues to fascinate him.
  12. Designing a Virtual Neuroscience Conference

    April 3, 2020
    Organizers mimic in-person networking using a matching algorithm.
  13. Tell Us About the Special

    April 1, 2020
    How the Simonses developed their own algorithm for excellence in science philanthropy.
  14. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    March 31, 2020
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  15. Reminder: Limitations on Using SFARI Simons Collection Datasets and/or Biospecimens

    March 27, 2020
    SFARI reminds all approved Principal Investigators that the use of data sets and/or biospecimens obtained from the SFARI Simons Collection is subject to certain limitations and that …
  16. A Conversation With SFARI Investigator Karen Parker

    March 27, 2020
    SFARI Investigator Karen Parker discusses her preclinical and clinical research on the neuropeptides arginine vasopressin and oxytocin as potential biomarkers and treatment strategies for autism spectrum disorder.
  17. SFARI Winter 2020 Pilot Awardees Announced

    March 26, 2020
    SFARI is pleased to announce that it intends to fund 11 grants in response to the Winter 2020 Pilot Award request for applications.
  18. Rachel Rosen on Black Holes and Alternative Theories of Gravity

    March 24, 2020
    In her studies of quantum field theory, Rachel Rosen of Columbia University tackles the black-hole information paradox, alternatives to Einstein’s theory of gravity and other puzzles …
  19. Autism Spectrum Disorder Risk Assessment Through Quantification of Sperm Mosaicism

    March 24, 2020
    Joseph Gleeson and colleagues used deep whole-genome sequencing and genotyping of sperm DNA to stratify ASD risk in offspring due to de novo mutation.
  20. Neural Encoding of Social Signals in Mice

    March 24, 2020
    Ofer Yizhar and colleagues described the altered dynamics of social representation in neurons of the medial prefrontal cortex of Cntnap2-null mice, a model of autism spectrum disorder.
  21. Note to SFARI Investigators Regarding COVID-19 Epidemic

    March 23, 2020
    SFARI is writing to assure you that the health and well-being of your lab members is very much in our minds during the COVID-19 epidemic. We …
  22. Neuroimmune Mechanisms in Autism Mouse Models

    March 23, 2020
    Gloria Choi, Jun Huh and colleagues showed that postnatal administration of IL-17a can rescue some of the anatomical and behavioral deficits observed in a maternal immune activation …
  23. A Cosmic Merger Over Vegan Sprouts

    March 23, 2020
    The director of the Simons Observatory describes the origin of the observatory, which aims to explain the origin of the universe.
  24. SFARI 2019 Director Awards Announced

    March 19, 2020
    SFARI is pleased to announce that 10 Director Awards were awarded in 2019. These projects include, but are not limited to, studies that aim to enhance existing SFARI …
  25. Inventing Tools for Others: Supercharging Studies of Autism Genetics

    March 19, 2020
    To speed discovery, SFARI decided to break the traditional approach in which each laboratory collects its own datasets and keeps them close to the vest.
  26. DYRK1A Family Meeting Supports Parents, and Scientists, Alike

    March 18, 2020
    On June 22, 2019, families of people with DYRK1A syndrome gathered in Seattle to support one another and meet with researchers. A rare condition resulting from mutations to …
  27. Zebras and the Environmental Pressures on Social Behavior

    March 17, 2020
    Two species of zebras sharing the same habitat have very different social patterns. Just how selection pressure from food, parasites, predators and other factors affect their behavior is …
  28. A Collaborative Checklist: How We Select Projects

    March 12, 2020
    Seven general criteria and considerations are top of mind when we decide on collaborations to support.
  29. Working as a Team: Collaborations as a Key to Breakthroughs

    March 12, 2020
    By bringing researchers together to focus on specific scientific goals, we hope to accelerate the pace of discovery.
  30. The Flatiron Institute: A Home for Computational Sciences

    March 9, 2020
    The institute has grown from a beautiful proposal into a bustling hub for computational science in astrophysics, biology, mathematics and quantum physics.
  31. A Quantum Continuation for Moore’s Law?

    March 2, 2020
    … ahead, with IBM, Google and Intel announcing devices with dozens of qubits made of superconducting circuits. Quantum supremacy, the demonstration of a calculation that a conventional computer …
  32. A Reckoning for Moore’s Law

    March 2, 2020
    Why upgrading your computer every two years no longer makes sense.
  33. A Conversation With Gerald Fischbach

    February 27, 2020
    We asked the foundation’s distinguished scientist, who joined us in 2006 to lead the Simons Foundation Autism Research Initiative (SFARI), to reflect on the initiative and its …
  34. Flatiron Institute’s David Spergel Named a Legacy Fellow of the American Astronomical Society

    February 26, 2020
    David Spergel, director of the Center for Computational Astrophysics (CCA), is among 232 astronomers and astrophysicists honored as the first class of fellows of the American Astronomical Society …
  35. How Do Deep Networks of AI Learn?

    February 26, 2020
    No one really knows how neural networks work, but a ‘DeepMath’ group of mathematicians, physicists, neuroscientists and engineers are trying to figure out how to decipher their powers.
  36. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    February 25, 2020
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  37. Studying Human Speech With Animals That Can’t Talk

    February 25, 2020
    Michael Long uses discoveries from songbirds, singing mice and other species to better understand different aspects of vocal communication.
  38. New Changes Implemented to SFARI Gene

    February 24, 2020
    SFARI has recently implemented a number of changes to SFARI Gene, including modification of the gene scoring, copy number variant, animal models and protein interaction modules. Curation of …
  39. Noise Hypersensitivity in PTCHD1-Associated ASD

    February 21, 2020
    Michael Halassa, Guoping Feng and colleagues identified a combinatorial strategy to reverse noise hypersensitivity in Ptchd1 knockout mice, while Stephen Scherer, James Ellis and colleagues separately explored the …
  40. Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder Have a Similar Profile of Rare Mutations

    February 21, 2020
    Mark Daly and colleagues used an exome sequencing data set of ASD and ADHD to identify a similar profile of rare protein-truncating variants in each disorder.
  41. 2020 Simons Fellows in Mathematics and Theoretical Physics Announced

    February 21, 2020
    … Elizabeth Meckes Case Western Reserve University Hee Oh Yale University Richard Schwartz Brown University Karl Schwede University of Utah Konstantinos Spiliopoulos Boston University Bianca Viray University of …
  42. Rethinking the Spectrum: Three Things We Thought Were True About Autism

    February 21, 2020
    The push to gain a deep understanding of the genetics and neurobiology of autism has forced scientists to reexamine three ideas about the condition.
  43. The Universe’s Dark Expanding Mystery

    February 20, 2020
    When it comes to the composition of the universe, we’ve made significant progress in finding out how little we know.
  44. Seeing Through a Forest of SCN2A Gene Variation

    February 19, 2020
    On August 2–3, 2019, people from around the world met in Seattle, Washington, to review recent findings about mutations to the sodium channel encoded by SCN2A. Organized …
  45. Many’s Not Too Many Anymore for Quantum Systems

    February 14, 2020
    Describing many-body quantum systems is generally next to impossible, physicists thought — until they realized that localized entanglement holds the key.
  46. Four Ways To Find New Worlds

    February 13, 2020
    RADIAL VELOCITY (‘WOBBLE’) METHOD Stars with planets will gravitationally tug on one another. A star’s wobble toward an observer blueshifts the observed light; movement away redshifts it …
  47. Our Solo System: Exoplanets Reveal How Unique We Are

    February 13, 2020
    Rocky planets inside, gas giants outside — we thought our solar system was typical. But the discovery of worlds around other stars has altered that view.
  48. Conference Spotlight: Cosyne 2020

    February 11, 2020
    Check out these talks and workshops featuring Simons Collaboration on the Global Brain, investigators, fellows and friends.
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