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SFARI Investigator Aakanksha Singhvi discusses her lab’s work and how the Bridge to Independence Award helped in her transition to working as an assistant professor. -
SFARI is pleased to announce that eight Director Awards were awarded in 2020. These projects include, but are not limited to, studies that aim to enhance existing SFARI … -
Stefano Panzeri and colleagues used neuroimaging-derived measures to assess the sex differential impact of excitation/inhibition imbalance in idiopathic ASD. -
Graeme Davis and colleagues showed that ASD risk genes genetically interact with a class of common modifiers of presynaptic homeostatic plasticity at the Drosophila neuromuscular junction. -
SFARI’s requests for grant applications (RFAs) will be undergoing a number of changes in 2021. These changes include the introduction of the new Human Cognitive and Behavioral … -
In this blog, Alice Luo Clayton assesses the first five years of the SFARI Bridge to Independence Award program, the impact the award has had on the fellows … -
SFARI is pleased to announce that it intends to fund 19 grants in response to the Summer 2020 Pilot Award request for applications. -
Phenotypic data from 251,082 participants enrolled in SPARK, including more than 99,000 individuals with ASD, are now available to approved researchers. -
New data were recently added to SFARI Gene. This data release included the addition of new genes associated with autism risk, new curated references of copy number variations … -
Charles Nelson, Helen Tager-Flusberg and colleagues assessed language development in infants at high risk and low risk of ASD. They reported parental mean length of utterance as … -
Gerald Crabtree, Joseph Gleeson and colleagues defined a new recessive form of ASD caused by mutations in ACTL6B, part of the BAF complex, which regulates activity-responsive transcription … -
Jessica Cardin and colleagues identified an important and unexpected role for the VIP subclass of interneurons in mediating the functions of MeCP2 in the development of cortical circuits. -
SFARI is pleased to announce that Simons Searchlight has launched a research matching program, through which researchers can apply to recruit individuals enrolled in Simons Searchlight into new … -
Beginning on October 1, 2020, the recipients of the SFARI Bridge to Independence Award gathered with SFARI staff and advisors for a virtual ‘retreat’ of six weekly webinars … -
SFARI is pleased to announce the 2021 Bridge to Independence (BTI) Award request for applications. The BTI Award program engages talented early-career scientists in autism research by … -
A number of presentations will be given by SFARI Investigators at the SfN Global Connectome: A Virtual Event (January 11–13). -
SFARI Investigator Kevin Eggan discusses his research on induced pluripotent stem (iPS) cells and his collaboration with SFARI to provide a detailed characterization of iPS cell lines from … -
On July 29, 2020, SFARI convened an online workshop to explore environmental (maternal and fetal) risk factors for autism spectrum disorder in the context of COVID-19 infection. -
John Rubenstein and colleagues identified WNT signaling as a key mediator of Tbr1-dependent functions in deep-layer cortical neurons, and showed that normalizing WNT signaling rescues particular … -
Kurt Haas and colleagues used multiple models and bioassays to assess the functional impact of more than 100 missense and nonsense mutations in PTEN, allowing for high-confidence … -
New Simons Searchlight data were recently added to SFARI Base. This data release included phenotypic data from individuals with 16p11.2 copy number variants (CNVs), 1q21.1 CNVs … -
Autism BrainNet has launched its newly redesigned website. The updated platform has an improved look and feel and new navigation features for a more pleasant, effective and informative … -
This powerful, dynamic software system is changing how scientists sift through the recent deluge of human genomic data — and deepening our knowledge of human biology, health and disease. -
New data were recently added to SFARI Gene. This data release included the addition of new genes associated with autism risk, new curated references of copy number variations …
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A number of SFARI Investigators, collaborators and Simons Foundation scientists will present their latest research findings at the American Society of Human Genetics (ASHG) 2020 Virtual Meeting, which … -
A new collaboration between SFARI and the Nancy Lurie Marks Family Foundation will generate hundreds of induced pluripotent stem cells from individuals with autism and related neurodevelopmental conditions … -
Kimberly Huber, Joel Richter and colleagues showed that FMRP deficiency in mice leads to changes in a key histone modification across the genome, with subsequent effects on alternative … -
Benjamin Blencowe and colleagues defined the functional roles of microexons in genes encoding translation initiation factors, linking them to altered translation, synaptic plasticity and behavior. -
Louis Reichardt, who has served as director of SFARI since 2013, finished his tenure here on September 28. John Spiro has been appointed interim director of SFARI until … -
Peter Kind and Loren Frank discuss their work using SFARI’s genetic rat models and their views on how these models will aid autism research. -
SFARI would like to remind investigators to please acknowledge SFARI funding and/or the use of SFARI resources, biospecimens and data in all relevant preprints and publications. -
Due to the COVID-19 pandemic, SFARI replaced the in-person spring 2020 science meeting that was scheduled April 5–7 with a series of seven weekly webinars … -
Eric Morrow, Stephen Sheinkopf and colleagues reported the characteristics of the first 1,000 participants in the RI-CART study, a population-based cohort of individuals with autism … -
Genevieve Konopka and colleagues reported important roles for Foxp1 in particular subclasses of the spiny projection neurons in the striatum, with downstream effects on striatal-dependent circuits and … -
SFARI is pleased to announce that eight genetic rat models of autism spectrum disorder are now available from the Medical College of Wisconsin. These models are being maintained … -
SFARI is pleased to announce that it has selected three fellows in response to the 2020 Bridge to Independence Award request for applications. -
New data were recently added to SFARI Gene. This data release included the addition of new genes associated with autism risk, new curated references of copy number variations …
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Garret Stuber and colleagues used in vivo calcium imaging to show that a population of oxytocin-positive (OT) neurons in the paraventricular nucleus of the hypothalamus responds preferentially … -
Michael Piper and colleagues confirmed and extended the association of USP9X loss-of-function mutations with a neurodevelopmental syndrome in both sexes, driven by changes in multiple signaling … -
Joseph Buxbaum and colleagues in the Autism Sequencing Consortium reported the largest exome sequencing study of ASD to date, identifying 102 risk genes at a false discovery rate … -
SFARI is pleased to announce that it intends to fund eight grants in response to the 2020 Research Award request for applications. -
SFARI would like to remind researchers that they can still request many SFARI resources, including genetic and phenotypic data as well as biospecimens, at this time. Researchers can … -
SFARI Investigators will be giving a number of presentations as part of the 12th FENS Forum of Neuroscience. Due to the COVID-19 pandemic, the forum will be … -
The International Society for Autism Research (INSAR) 2020 Annual Meeting to be held May 2020 was canceled, but virtual content is now available online. A selection of abstracts … -
On February 6–7, 2020, SFARI convened a two-day workshop to explore the possibility of gene therapies for autism spectrum disorder. -
Gina Turrigiano and colleagues showed that loss of Shank3 disrupts homeostatic plasticity and that this deficit can be rescued by the mood-stabilizing drug lithium (Li+). -
A SFARI Investigator and a past member of SFARI’s Scientific Advisory Board are among the 146 newly elected members of the National Academy of Sciences. -
Three current and former SFARI Investigators and one member of SFARI’s Scientific Advisory Board are among the 276 newly elected members of the American Academy of Arts …