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Autism as a neurodevelopmental disorder causes significant reduction in reproductive rate among affected individuals.

Autism is a genetically heterogeneous condition, with contributions from de novo variants, inherited rare variants, and polygenic common variation.

Autism is a highly heritable condition that emerges during infancy and toddlerhood, a fundamental period for brain development in all children.

Most genetic risk for autism reflects the aggregate activity of thousands of common genetic differences distributed throughout the genome.

This project combines deep learning models of gene regulation with the whole-genome sequences (WGS) and phenotypes of the SPARK cohort to test the hypothesis that de novo …

Trisomy rescue, a process in which somatic cell divisions correct zygotic trisomies by discarding an extra chromosome, can generate mosaic chromosomal abnormalities with profound consequences for neurodevelopment.

De novo protein coding mutations are a major contributor to autism, and the characterization of these mutations is a major goal of SPARK and other large-scale genetic …

Sleep disturbances, primarily insomnia (difficulty initiating or maintaining sleep), are reported in up to 80 percent of children with autism spectrum disorder (ASD).

Autism spectrum disorder (ASD) has a complex genetic architecture, yet a significant fraction of cases remain unexplained.

Despite the use of genome-wide sequencing, families who present to genetics clinics seeking to understand the cause of the autism or intellectual disability (ID) in their family …

While hundreds of autism risk genes have been identified through analysis of de novo variants in probands with autism, understanding of the molecular mechanisms underlying these genetic contributions …

An open question in brain disorder research is whether behavioral phenotypes in animal models are conserved across species.

Autism spectrum disorder (ASD) remains largely unexplained at the molecular level, with whole-exome and whole-genome sequencing (WES/WGS) offering relatively low diagnostic yield.

Public Series Presidential Lectures Presidential Lectures are a series of free public colloquia spotlighting groundbreaking research across four themes: neuroscience and autism science, physics, biology, and mathematics and …

The catch? Once they enter the any colony, the beetles can never leave.

In a new preprint, GPT‑5.2 proposed a formula for a gluon amplitude later proved by an internal OpenAI model and verified by the authors.

A study published in the journal Nature Neuroscience reveals that the geometry of brain activity patterns determines how well knowledge transfers to new situations, and presents a single …

… learning-related differences in sensory function. By revealing how disrupted cortical–midbrain communication interferes with the flexible interpretation of environmental cues, this work offers a framework for …

These awards support interdisciplinary research into the sex bias associated with autism and its underlying biological mechanisms.

What connects Bloomington, Indiana to Buffalo, New York? Or Austin, Texas to Akron, Ohio? At a surface level, it may not be much. But for a few minutes …

The biological basis of the sex bias in autism (ASD) remains unclear.

The tool extends the capabilities of AlphaFold — a Nobel Prize–winning AI that predicts how proteins fold — by directly learning from raw experimental data.

In young children, ASD is diagnosed approximately four times more frequently in boys than girls, yet the underlying mechanism for this sex skewing is unclear.

Males are four times as likely as females to be diagnosed with autism, and females require significantly more autosomal genetic risk to manifest autism.

Autism genetics research faces two major challenges: understanding the higher male:female ratio in non-syndromic autism and finding the genetic basis for the 70% of non-syndromic …

… SVs4, making it difficult to identify those relevant to disease. Comparing variants within families and against hundreds of long-read reference pangenomes allowed the team to filter …

Previous research has found large differences in ASD sex ratios by age of diagnosis.

With warmer ocean temperatures, the composition of marine plankton could shift from protein-rich to carb-heavy, a new study suggests.

A new atlas of aging in the killifish tracks how organs change over time, revealing processes implicated in Alzheimer’s and Parkinson’s diseases. The study also creates …

… and commitment to the foundation’s mission.

… Cerbo about the broad array of technologies needed to understand neuroscience. At the time, “I found myself really drawn to the different techniques and protocols to better …

Recent SFARI-funded research challenges the idea that autism represents a single condition driven by a uniform set of genetic risk factors. Instead, the results support a developmental …

The Simons Foundation is now accepting applications from undergraduate students to participate in its Shenoy Undergraduate Research Fellowship in Neuroscience (SURFiN) program for the 2026–2027 academic year …

SFARI-funded research demonstrates that activating serotonergic 5HT2c receptors leads to an increase in intracellular calcium, early-response gene expression and elevated protein secretion into cerebrospinal fluid.

Huang explores how symmetries and structure can help reveal new insights into the universe, aiding discovery in everything from cosmology to the development of fusion energy.

… PAG-organized conference, you can explore the Conference Grant Support for Rare Neurodevelopmental Disorder Communities Participating in Simons Searchlight RFA. Applicants must submit a letter of intent …

The Simons Foundation is now accepting applications for the next class of Pivot Fellows, offering a unique opportunity for researchers ready to bring their expertise to a new …

A new study reveals that the geometry of brain activity patterns determines how well knowledge transfers to new situations, and presents a single mathematical formula that captures this …

The Simons Foundation is supporting events nationwide and co-producing an event with the Brooklyn Public Library featuring a keynote by filmmaker Werner Herzog.

… that Quanta has released over the last two years. September 2024’s “The Unraveling of Space-Time” received the National Magazine Award for Best Single-Topic Issue …

The Simons Foundation We’re a philanthropic organization dedicated to advancing the frontiers of math and basic science through grantmaking, in-house research and public engagement.

We leverage advanced computational methods, open-source tools and deep collaboration to power scientific research into everything from neurons to galaxy clusters.

Media Contact Journalists with inquiries about the Simons Foundation, the Flatiron Institute or who need help finding a subject-matter expert can email us at [email protected] …

Mission and Model The Simons Foundation’s mission is to advance the frontiers of research in mathematics and the basic sciences. Since its founding in 1994 by Jim …

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Nuclear fusion reactors hold the promise of abundant, low-emission energy, but many obstacles remain before they will be viable for practical use. Since its inception in 2018 …

Meet the artists, scientists, and arts organizations selected to produce new artworks in connection with the Simons Foundation’s Infinite Sums initiative.

A new preprint shows that a type of particle interaction many physicists expected would not occur can in fact arise under specific conditions. The work focuses on gluons …