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Bringing people and ideas together to fund, conduct, and share transformative science.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Placental neurosteroids in autism

    Funded Work
    Placental dysfunction is highly associated with abnormal fetal brain development and neurodevelopmental disorders such as autism.
  2. Circuit mechanisms mediating social attachment deficits in ASD

    Funded Work
    Disruptions in social attachment and cognition occur in the context of autism spectrum disorder (ASD).
  3. The role of the LC-NE system in perceptual deficits in a SHANK3 mouse model

    Funded Work
    Atypical sensory processing is widely observed in individuals with autism spectrum disorder (ASD) although the underlying biological mechanisms are unknown.
  4. Testing computational theories of visual processing in ASD with a novel integrated approach

    Funded Work
    A fundamental function of sensory systems is to segment sensory inputs into distinct perceptual objects (termed perceptual grouping and segmentation, PGS).
  5. Flatiron Institute Becomes New Hub for Stellar Evolution Software Suite MESA

    March 31, 2025
    … Paxton’s retirement and beyond — and fostering a community of users and developers through workshops, events and training. “I never imagined MESA would have so many users …
  6. Simons Sleep Project Releases Data About Sleep Behaviors and Autism

    March 27, 2025
    The Simons Foundation Autism Research Initiative (SFARI) is pleased to announce the release of data collected from its Simons Sleep Project (SSP), a study aimed at accelerating research …
  7. Inside arXiv—the Most Transformative Platform in All of Science

    Wired
    Modern science wouldn’t exist without the online research repository known as arXiv. Three decades in, its creator still can’t let it go.
  8. Applications Open for 2025–2026 Undergraduate Research Fellowships in Neuroscience

    March 27, 2025
    The Simons Foundation is now accepting applications from undergraduate students to participate in its Shenoy Undergraduate Research Fellowship in Neuroscience (SURFiN) program for the 2025–2026 academic year …
  9. Joy Bergelson Named Head of Simons Foundation’s Life Sciences Division

    March 24, 2025
    … project that detailed whole-genome sequence variation in the plant. Bergelson serves on science advisory boards for TULIP INRAE in France, MiCROP in the Netherlands, the Blavatnik …
  10. These Mathematical Equations Are Slashing America’s Electric Bills

    March 24, 2025
    Fundamental research on the mathematics of waves led to the development of the ‘landscape function,’ which has quickly revolutionized the engineering of power-efficient LED lightbulbs.
  11. New Model Predicts How Bacteria Navigate Obstacles To Spread

    March 21, 2025
    A Flatiron Institute scientist has developed the first analytical model for predicting how bacteria spread in environments filled with obstacles. This model will help inform strategies for curbing …
  12. Clarifying a Plankton Paradox Reveals Climate Risks, Santa Fe Institute

    In the News
    The oceans teem with photosynthesizing bacteria, tiny-tailed dinoflagellates gobbling other plankton, algae surrounded by intricate glass skeletons. In the 1960s, the ecologist G. Evelyn Hutchinson pointed out …
  13. Atacama Cosmology Telescope Publishes Final Major Data Release

    March 18, 2025
    The latest data from the Atacama Cosmology Telescope collaboration includes the clearest and most precise measurements yet of the universe’s earliest light.
  14. Simons Observatory Large Aperture Telescope Achieves First Light Milestone

    March 17, 2025
    … achieve the gamut of the SO science objectives, the SO team designed the LAT and its camera to have unprecedented sensitivity and excellent optical quality.” The LAT …
  15. Paul Wang To Take on New Role in SFARI Pharmaceutical and Biotech Relations

    March 11, 2025
    Paul Wang has assumed the role of Senior Scientific Director, SFARI Pharmaceutical and Biotech Relations.
  16. Ellen Taus Joins Simons Foundation Board of Trustees

    March 10, 2025
    The Simons Foundation is pleased to announce that financial executive Ellen Taus has joined its board of trustees. Taus was the Rockefeller Foundation’s chief financial officer and …
  17. CCM Researchers Win Competition To Map Neural Connections in Fruit Fly Brain

    March 7, 2025
    … opportunity to showcase the style of research that is done within CCM and the Flatiron Institute more broadly. “The competition aligned perfectly with the mission of Flatiron …
  18. SCOPE Synthesis: Causes and consequences of a shifting iron cycle in the North Pacific during the SCOPE era

    Funded Work
  19. Elucidating the unknown mechanisms of viral resistance in algal blooms in the ocean

    Funded Work
  20. SCOPE Synthesis: Emerging patterns in the diversity, activity, and community interactions of marine nitrogen fixers

    Funded Work
  21. SCOPE Synthesis: Synthesis of microbial biogeochemical results from SCOPE

    Funded Work
  22. SCOPE Synthesis: Metabolomics as a tool for understanding microbial communities of the North Pacific

    Funded Work
  23. SCOPE Synthesis: Causes and consequences of a shifting iron cycle in the North Pacific during the SCOPE era

    Funded Work
  24. SCOPE Synthesis: SCOPE ALOHA ‘omics time-series analyses and cruise integration analyzing marine picoplankton in the North Pacific Subtropical Gyre

    Funded Work
  25. SCOPE Synthesis: Phytoplankton interaction networks along Gradients transects

    Funded Work
  26. SCOPE Synthesis: Microbial control of nitrogen and iron cycling in the North Pacific Ocean

    Funded Work
  27. SCOPE Synthesis: Protistan Community Ecology in the NPSG

    Funded Work
  28. SCOPE Synthesis: Evaluating the role of cyanophages in shaping the ecology and biogeochemistry of the North Pacific Ocean

    Funded Work
  29. Eco-evolutionary virus-microbe dynamics on a continuum from lysis to latency

    Funded Work
  30. Simons Foundation Now Accepting Applications for Fourth Class of Pivot Fellows

    March 3, 2025
    The Simons Foundation and Simons Foundation International are now accepting applications for the next class of Pivot Fellows. The program provides funding for today’s brightest minds to …
  31. Mechanisms involved in nitroplast evolution

    Funded Work
  32. What Can Theoretical Physics Teach Us About Knitting?, Penn Today

    In the News
    Penn physicist Randall Kamien, visiting scholar Lauren Niu, and collaborator Geneviève Dion of Drexel bring unprecedented levels of predictability to the ancient practice of knitting by developing a …
  33. Leaders across Science, Industry, Academia, Philanthropy and Public Sector Release Vision for American Science and Technology

    February 25, 2025
    Policy recommendations from the bipartisan, cross-sector group aim to ensure the U.S. remains the world leader in science and technology and secures its national security and …
  34. CCN’s NeuroRSE Group Hosts Two Software Workshops

    February 25, 2025
    The NeuroRSE group at the Flatiron Institute’s Center for Computational Neuroscience (CCN) recently hosted two software workshops that taught scientists how to analyze neuroscience data using new …
  35. CCM Scientist Jiequn Han Receives Early Career Prize From Society of Industrial and Applied Mathematics

    February 24, 2025
    … machine learning.”
  36. How Do Our Brains Make Decisions? The International Brain Laboratory Is Closing In on Answers

    February 20, 2025
    The collaboration of 19 laboratories and dozens of neuroscientists has collected data that could reveal how regions throughout the brain behave during the decision-making process.
  37. CCM Group Leader Marsha Berger Named 2025 John von Neumann Prize Lecturer by Society of Industrial and Applied Mathematics

    February 13, 2025
    … grateful to be recognized by my peers,” she says. “Knowing that my work has been used and helpful to others is a big motivator for me.”
  38. Princeton Geoscientists Propose an Unexpected New Screening Tool for Cancer, Princeton University

    In the News
    Princeton geoscientists Xinning Zhang and Ashley Maloney have discovered that a geology technique shows promise in detecting cancer-like cells. If their preliminary results bear out, they may …
  39. Study Led by SCOPE PI Jonathan Zehr Wins AAAS’s Newcomb Cleveland Prize

    February 12, 2025
    … postdoctoral work at Stony Brook University, Brookhaven National Laboratory and New England Biolabs, Inc. He is currently a distinguished professor emeritus in the Department of Ocean Sciences …
  40. New Research Identifies a Key Player in How Your Brain Ages: The X Chromosome

    February 5, 2025
    Whether you inherit your X chromosomes from your mother or from both parents could impact brain aging and cognition, pointing to potential strategies for preserving healthy brain function.
  41. We Embedded Artists Into Complex Science Meetings — Here’s What They Produced

    February 4, 2025
    In this Q&A, illustrators Alex Eben Meyer and Jun Cen talk about the process of working alongside physicists and mathematicians.
  42. CCA Researcher Lorenzo Sironi Receives Presidential Early Career Award for Scientists and Engineers

    February 3, 2025
    The White House announced on January 14 that Flatiron Institute astrophysicist Lorenzo Sironi will receive the Presidential Early Career Award for Scientists and Engineers (PECASE), the highest honor …
  43. Boosting myelination as a therapeutic strategy in autism

    Funded Work
    Myelin, the lipid bilayer wrapping axons, contributes to increasing the conduction velocity of axons and to providing axonal metabolic support.
  44. Announcing Quanta Books, a New Imprint Dedicated To Illuminating Science

    January 29, 2025
    The new partnership between the Simons Foundation and book publisher Farrar, Straus and Giroux will release science and math books that entice and inspire readers. The imprint’s …
  45. 5 Simons-Supported Investigators Receive Awards From National Academy of Sciences

    January 27, 2025
    … Origins of Life (SCOL) Sutherland will receive the NAS Award in Early Earth and Life Studies — Stanley Miller Medal for advancing our understanding of the chemical origins …
  46. How Science Revealed a Simple Universe, World Science Festival

    In the News
    Renowned cosmologist David Spergel joins Brian Greene to discuss the triumphs and tensions of precision cosmology, exploring remarkable successes as well as persistent discrepancies bedeviling current understanding.
  47. Announcing the 2025 Simons Foundation Presidential Lecture Series

    January 22, 2025
    Created for the NYC research community, these free lectures highlight the latest research in mathematics and basic science.
  48. Hubble Telescope’s Jaw-Dropping New Photo Mosaic Traces Andromeda Galaxy’s History

    January 16, 2025
    On a chilly, crystal-clear autumn night, you can see the farthest object visible in the universe without the aid of a telescope or binoculars. Just to the …
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