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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. How Flatiron Institute Mathematicians Helped Make AI More Efficient

    August 17, 2026
    The Muon optimizer, a community effort including scientists at the Simons Foundation’s Flatiron Institute, is poised to be the new standard in AI training efficiency.
  2. Nour Al Hassanieh: Using Wave Dynamics To Improve Medical Imaging

    August 10, 2026
    Flatiron Research Fellow Nour Al Hassanieh develops accurate and efficient algorithms for solving wave equation problems, an endeavor with many potential applications.
  3. Mathematicians Unleash Multifold Speed Boost for Supercomputer Simulations of Molecules

    June 24, 2026
    By leveraging a classical mathematical function in simulations of molecular behavior, researchers at the Simons Foundation’s Flatiron Institute drastically sped up the simulations while maintaining the same …
  4. Beyond the Cryo-EM Resolution Revolution

    June 23, 2026
    … cryo-EM data. To create the most useful tools, Flatiron researchers brought together an interdisciplinary cohort of investigators to provide input. Cossio and computational biophysicist Sonya Hanson …
  5. Alumni Spotlight: Gokberk Kabacaoglu

    May 15, 2026
    Kabacaoglu, a former research fellow at the Simons Foundation’s Flatiron Institute, is now an assistant professor in the Department of Computer Science at Durham University in England …
  6. Pilar Cossio: Reconstructing RNA’s Shapeshifting Behavior

    April 28, 2026
    Flatiron Institute Senior Research Scientist Pilar Cossio builds tools to analyze experimental measurements and reveal how environmental changes alter the behavior of RNA molecules.
  7. American Academy of Arts and Sciences Elects CCM’s Charles Epstein

    April 23, 2026
    Mathematician Charles Epstein of the Simons Foundation’s Flatiron Institute was elected to the American Academy of Arts and Sciences on April 22. He joins leaders in the …
  8. Introducing ROCKET: An Upgrade to AlphaFold That Learns From Raw Experimental Data

    April 1, 2026
    The tool extends the capabilities of AlphaFold — a Nobel Prize–winning AI that predicts how proteins fold — by directly learning from raw experimental data.
  9. Teresa Huang: Bridging Science and Machine Learning at Cosmic Scales

    March 4, 2026
    Huang explores how symmetries and structure can help reveal new insights into the universe, aiding discovery in everything from cosmology to the development of fusion energy.
  10. CCM Distinguished Research Scientist Stéphane Mallat Awarded CNRS Gold Medal

    September 17, 2025
    The medal recognizes Mallat’s scientific contributions, including his research into wavelets and the geometry of data.
  11. Tsunamis, Landslides and Asteroid Impacts: GeoClaw Models Deadly Flows

    July 30, 2025
    The open-source modeling platform GeoClaw enables scientists to predict and prepare for deadly natural disasters by simulating complex geophysical flows.
  12. CCM Researchers Win Competition To Map Neural Connections in Fruit Fly Brain

    March 7, 2025
    … opportunity to showcase the style of research that is done within CCM and the Flatiron Institute more broadly. “The competition aligned perfectly with the mission of Flatiron …
  13. CCM Scientist Jiequn Han Receives Early Career Prize From Society of Industrial and Applied Mathematics

    February 24, 2025
    … machine learning.”
  14. CCM Group Leader Marsha Berger Named 2025 John von Neumann Prize Lecturer by Society of Industrial and Applied Mathematics

    February 13, 2025
    … grateful to be recognized by my peers,” she says. “Knowing that my work has been used and helpful to others is a big motivator for me.”
  15. New Datasets Will Train AI Models To Think Like Scientists

    December 2, 2024
    The Polymathic AI team has released two massive datasets for training artificial intelligence models to tackle problems across scientific disciplines. The datasets include data from dozens of sources …
  16. Astrophysicists Use AI To Precisely Calculate Universe’s ‘Settings’

    August 26, 2024
    The new estimates of the parameters that form the basis of the standard model of cosmology are far more precise than previous approaches using the same galaxy distribution …
  17. CCM and CCN Researchers Awarded Outstanding Paper Award at the International Conference on Learning Representations

    May 7, 2024
    The International Conference on Learning Representations (ICLR) honored Center for Computational Neuroscience (CCN) research fellow Florentin Guth, CCN guest researcher Zahra Kadkhodaie, Center for Computational Mathematics (CCM) distinguished …
  18. One Model To Rule Them All: Creating a Machine Learning Foundation Model for Science

    March 11, 2024
    Flatiron Institute computational mathematician Ruben Ohana is working within the Polymathic AI team to create foundation models that can help scientists solve a range of problems from climate …
  19. All Five Flatiron Centers Represented at the Conference on Neural Information Processing Systems (NeurIPS)

    December 8, 2023
    For the first time, the five Flatiron Institute research centers (astrophysics, biology, mathematics, neuroscience and quantum physics), as well as its Scientific Computing Core and the Foundation Models …
  20. Learning Better: Improving the Efficiency of Deep Learning Models

    October 31, 2023
    Flatiron Research Fellow Brett Larsen is developing better ways to train deep learning models.
  21. Between Knowing Nothing and Knowing for Sure: The Science of Uncertainty

    June 12, 2023
    Flatiron Institute Research Fellow Charles Margossian is bringing the power of statistics to the people, empowering them to know when they’re on the right track to discovery.
  22. The Ups and Downs of Modeling Oscillation

    May 9, 2023
    Flatiron Institute Research Fellow Fruzsina Agocs develops mathematical tools to help scientists understand oscillating systems — from the earliest moments of our universe to how sound bounces off complicated …
  23. Stepping in the Right Direction: Optimizing Machine Learning

    March 7, 2023
    Flatiron Institute mathematician Neha Wadia is developing a new set of learning algorithms to improve machine learning optimization.
  24. CCM Director Leslie Greengard Awarded ICIAM Pioneer Prize

    January 31, 2023
    … applications, from chip simulation to molecular modeling. In 2000, the Institute of Electrical and Electronics Engineers recognized the FMM as one of the top ten algorithms of …
  25. Old Problems, New Tools: Adapting Applied Mathematics for Quantum Physics

    September 19, 2022
    Flatiron applied mathematician Jason Kaye is bringing powerful new approaches to quantum physicists to help them answer big questions about small particles.
  26. Computational Chemist Erik Thiede Named a Finalist for Blavatnik Regional Award for Young Scientists

    September 21, 2021
    The Blavatnik Family Foundation and the New York Academy of Sciences have named computational chemist Erik Thiede as a finalist for the 2021 Blavatnik Regional Award for Young …
  27. Scoring the Brain: How Benchmark Datasets and Other Tools Are Solving Key Challenges in Neuroscience

    August 25, 2021
    With standardized datasets, community-building challenges and simplified software bundles, research initiatives strive to bring uniformity to analysis in neuroscience.
  28. CCM’s Alex H. Barnett, Joakim Andén Among Authors To Win Best Paper Award at the PDSEC-21 Conference

    May 18, 2021
    CCM’s Alex Barnett and Joakim Andén along with collaborators at NYU, Princeton University, and the Lawrence Berkeley National Laboratory (LBNL) have received the Best Paper Award at …
  29. New Application of Artificial Intelligence Just Removed One of the Biggest Roadblocks in Astrophysics

    May 4, 2021
    Using neural networks, Flatiron Institute research fellow Yin Li and his colleagues simulated vast, complex universes in a fraction of the time it takes with conventional methods.
  30. CCB and CCM Collaborate To Create the New Structural and Molecular Biophysics Team

    February 4, 2021
    Underlying all biological processes are molecules and their interactions with each other. However, our ability to understand how these molecules function over biologically relevant scales remains very limited …
  31. Marsha Berger Joins CCM As New Group Leader

    January 21, 2021
    We are excited to announce the appointment of Marsha Berger as a new group leader in the Center for Computational Mathematics (CCM) at the Flatiron Institute. Berger is …
  32. Flatiron Research Fellow Jun Wang Joins the Yau Faculty of Mathematical Sciences Center at Tsinghua University

    October 21, 2020
    Congratulations to Jun Wang, who has just moved to her new job as an assistant professor at the Yau Mathematical Sciences Center at Tsinghua University in Beijing. Wang …
  33. Simons-Funded Researchers Elected as 2020 Fellows of the American Academy of Arts and Sciences

    April 27, 2020
    Seven researchers supported by the Simons Foundation and board member Margaret Hamburg are among the latest group of prominent artists, scholars, scientists and leaders elected as fellows of …
  34. The Flatiron Institute: A Home for Computational Sciences

    March 9, 2020
    The institute has grown from a beautiful proposal into a bustling hub for computational science in astrophysics, biology, mathematics and quantum physics.
  35. Open-Source Software Tracks Neural Activity in Real Time

    February 28, 2019
    The tool, called CaImAn, replaces the process of manually tracking the location and activity of neurons.
  36. Stéphane Mallat Appointed as CCM Distinguished Research Scientist

    December 3, 2018
    The Simons Foundation is pleased to announce the appointment of Stéphane Mallat as Distinguished Research Scientist at the Center for Computational Mathematics (CCM) at the foundation’s Flatiron …
  37. Flatiron Institute Launches Center for Computational Mathematics

    October 1, 2018
    … units came up with computational mathematics, I was dubious at first but was gradually persuaded that such a unit would act like glue, holding the whole institute …
  38. Flatiron Hosts First MountainSort Users Workshop

    May 24, 2018
    On May 17, 2018, nineteen users of our spike-sorting software package gathered at CCB from eight different neuroscience laboratories from across the US and UK. We discussed …
  39. Neuropixels Developer James Jun Joins CCB’s Numerical Algorithm Group

    February 8, 2018
    The Flatiron Institute is pleased to announce that Jaeyoon James Jun will join the Center for Computational Biology (CCB) as a postdoctoral fellow with the Numerical Algorithms group.
  40. Mathematician Alex Barnett Joins CCB as Leader of Numerical Algorithms Group

    October 3, 2017
    The Flatiron Institute is delighted to announce that Alex Barnett has joined the Center for Computational Biology (CCB) as group leader for the Numerical Algorithms group. Barnett is …

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