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Autism BrainNet has begun distributing postmortem brain tissue to qualified investigators working on autism and related neurodevelopmental disorders. Initially, distributed tissue will be restricted to donations previously collected …

Joseph Gleeson and colleagues have generated a publically accessible whole-exome variome from 1,111 unrelated individuals within the Greater Middle East Variome Consortium.

This issue of the SFARI newsletter includes: (1) Autism BrainNet begins tissue distribution, (2) SFARI Gene update, (3) A Conversation with Pamela Feliciano, Scientific Director of SPARK, (4 …

New data were added to SFARI Gene in June. This data release included the addition of new human genes implicated in autism, new animal models, and new protein …

Alan Packer, senior scientist at SFARI, discusses a number of recent review articles that provide interesting and complementary overviews of what we currently know about the neurobiology of …

Pamela Feliciano discusses the motivation behind SPARK and insights gained from the initial phases of the project.

David Ginty shows that four different mice harboring mutations in ASD risk genes have altered peripheral sensory neuron processing that contributes to ASD-like phenotypes.

Christian Luscher and Camilla Bellone show that ASD- model mice with reduced SHANK3 in the VTA have altered excitatory synapse transmission and impaired social behaviors.

This issue of the SFARI newsletter includes: (1) 2016 Bridge to Independence Award request for applications, (2) SFARI Blog: SFARI supports preprints for the life sciences, (3) Highlights …

Dan Arking compares large-scale transcriptome datasets from neurotypical individuals and those with autism, schizophrenia and bipolar disorder.

Using fMRI in typically developing children, Vinod Menon finds one’s mother’s voice activates a network of brain regions predictive of a child’s social communication skills.

SFARI’s deputy scientific director, John Spiro, outlines two important changes that have been implemented in light of SFARI’s support for preprints of life science research findings …

Michael Wigler and Dan Levy develop a new fragmentation and sequencing method for CNV analysis that generates high-resolution CNV data at lower cost than traditional analyses.

Benjamin Philpot shows that seizure susceptibility in an Angelman syndrome mouse model results from the specific loss of UBE3A from GABAergic, but not glutamatergic, neurons.

Simons Center for Data Analysis scientist Richard Bonneau develops a method to assess disease gene variants that combines sequence analysis and protein structural modeling.

Guoping Feng and Michael Halassa create mice with global or thalamic-specific loss of the ASD-risk gene PTCHD1 to show specific roles for thalamic PTCHD1 in ASD …

SFARI today announced the launch of SPARK, an online research initiative designed to become the largest autism study ever undertaken in the United States. SPARK will collect information …

This issue of the SFARI newsletter includes: (1) SFARI launches SPARK, an online research initiative that aims to recruit 50,000 individuals with autism, (2) Upcoming lecture: Christopher …

Mark Daly compares genetic data of social and communication difficulties in healthy individuals with ASD genetic data to show how risk variants lead to a behavioral continuum.

By comparing phenotypes in 25 individuals with de novo mutations in POGZ with SSC ASD phenotypic data, Evan Eichler uncovers a distinct POGZ-ASD clinical subtype.

SFARI is pleased to announce that it has selected six finalists in response to the Bridge to Independence Award request for applications. This new awards program is intended …

This issue of the SFARI newsletter includes: (1) SFARI announces Bridge to Independence Award finalists, (2) Exome sequencing data from the Simons Simplex Collection now available online, (3 …

Whole-exome sequencing and associated phenotypic data from the Simons Simplex Collection (SSC) are now accessible via WuXi NextCODE’s cloud-based database. This new platform allows researchers …

Dan Littman and colleagues use a mouse maternal immune activation (MIA) model to dissect immune pathways linking MIA with autism risk.

Using SHANK3 conditional knock-in mice, Guoping Feng shows that adult re-expression of SHANK3 improves cellular and behavioral abnormalities, including ASD-like deficits.

James Gusella and Michael Talkowski develop a CRISPR/CAS9 genomic method to generate microdeletions and microduplications in human iPSCs that mirror human CNV genetics.

Evan Eichler compares whole-genome and whole exome sequencing data of ASD indivduals and finds an enrichment of variants in putative noncoding regulatory elements in ASD.

The Autism Inpatient Collection, directed by Matthew Siegel, enrolls individuals severely affected by autism, facilitating assessment of this under-represented group.

Irving Reti assesses, in two ASD mouse models, the utility of targeted, subthalamic nucleus, deep brain stimulation to treat severe forms of self-injurious behavior.

Sandeep Robert Datta describes a combined 3D computer vision/machine-learning method that identifies behavioral modules expressed by freely behaving mice.

SFARI is pleased to announce that it has awarded four grants in response to the Novel Outcome Measures for ASD Clinical Trials request for applications. These grants will …

This issue of the SFARI newsletter includes: (1) SFARI announces Novel Outcome Measures for ASD Clinical Trials awardees, (2) SFARI-funded publications.

This issue of the SFARI newsletter includes: (1) SFARI announces Functional Screen of Autism-Associated Variants awardees, (2) SFARI Blog: Making sense out of missense mutations.

SFARI is pleased to announce that it has awarded five grants in response to the Functional Screen of Autism-Associated Variants request for applications. These grants will support …

SFARI launched a request for applications in early 2015 that sought proposals to develop medium- and high-throughput screens to test the functional effects of de novo missense …

SFARI is pleased to announce that it has awarded five grants in response to the Whole-Genome Analysis for Autism Risk Variants request for applications. We are also …

This issue of the SFARI newsletter includes: (1) SFARI announces Whole-Genome Analysis for Autism Risk Variants awardees, (2) Availability of whole-genome sequencing data from the Simons …

SFARI is pleased to announce that it has awarded 28 grants (15 Pilot Awards and 13 Research Awards) in response to the 2015 Pilot and Research Awards request …

This issue of the SFARI newsletter includes: (1) SFARI 2015 Pilot and Research awardees announced, (2) Autism BrainNet and NIH NeuroBioBank partner to advance autism research, (3) SFARI …

Simons Foundation and Autism Speaks have entered into an agreement with the National Institutes of Health to align two of the world’s largest repositories of donated postmortem …

Lectures and symposium presentations that will be given by SFARI Investigators at Neuroscience 2015 in Chicago (17-21 October 2015) are highlighted.

Today, we’re announcing our annual request for applications (RFA) for SFARI Pilot and Research Awards. Letters of intent (LOIs), the short statements that precede full applications, are …

SFARI held its seventh science meeting from April 12-14, gathering together more than 100 SFARI-supported autism researchers.

The Simons Foundation is supporting the launch of the Kaiser Permanente Autism Family Research Bank, a project to gather genetic material from 5,000 families who have a …

SFARI hosted a Circuit Dynamics Workshop to explore the role of neural circuits in autism.

SFARI gathered together some 250 current and prospective autism researchers for a social on November 17 at the Society for Neuroscience’s 2014 annual meeting in Washington, D …

An unparalleled gene-sequencing study of autism families has identified dozens of high-confidence autism genes, and hundreds more worthy of study.

NextCODE allows users to access online datasets at full resolution without sending big files, enabling them to use the full power of next-generation sequencing data to better …