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Timothy Roberts and his colleagues at the Children’s Hospital of Philadelphia are studying the responsiveness of neural oscillatory measures to acute administration of STX209 (arbaclofen), a GABAB …

It is well established that homeostatic signaling systems interface with the mechanisms of developmental and learning-related plasticity to achieve stable yet flexible neural function and animal behavior.

The Autism Biomarkers Consortium for Clinical Trials (ABC-CT) is a multicenter research study based at Yale University that spans Duke University, Boston Children’s Hospital, the University …

Whole-exome sequencing studies of sporadic autism cases have identified SCN2A, which encodes the neuronal voltage-gated sodium channel NaV1.2, as one of the most commonly mutated …

Ivan Iossifov studies the genetics of autism using the large datasets produced with comparative genomic hybridization, whole-exome and whole-genome sequencing of the extensively phenotyped Simons Simplex …

Fei Xu and her colleagues conduct research on early cognitive and language development in typically developing infants and children.

The cause of autism is thought to involve a combination of both genetic and environmental factors.

The Kaiser Permanente Autism Family Biobank Study is a three-year project at Kaiser Permanente Northern California.

Although mutations — the fundamental process by which genomic variation is acquired — are necessary to the evolution and success of a species, they are also the origin of all …

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Mobile lab that brings hands-on science to underserved students in New York City, with a research lab base on the Lower East Side and in Harlem.

Anatomical and electrophysiological studies have made it clear that dysfunction in the cerebellum, and in Purkinje cells specifically, is linked to behavioral abnormalities in autism.

Although autism is characterized primarily by impairments in social skills and communication, as well as restricted interests and repetitive behaviors, it has become evident that attention abnormalities may …

Multiple autism spectrum disorders share similar neuronal deficits at the molecular and cellular levels.

Reciprocal copy number variation (CNV), or duplication or deletion, of the 16p11.2 region of chromosome 16 causes a multi-system genomic disorder.

In the human brain, billions of neurons wired into networks sense the environment; process, store, and retrieve information; and produce thoughts and behavior.

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When we perceive a face, we see multiple aspects, such as its location in space, its overall 3-D shape, and the color of the lips and eyes.

How does the activity of neurons give rise to cognitive phenomena such as short-term memory or decision-making?

Neural networks in the brain have their own intrinsic activity independent of incoming sensory stimuli.

Neural pathways are composed of hundreds, thousands, or millions of neurons.

The human brain is composed of billions of neurons.

The behavioral repertoire of any animal is ultimately determined by the activity of its brain cells.

The activity of neurons in the brain represents external sensory stimuli, internal cognitive states, and plans for upcoming motor behavior.

The cerebral cortex—the outermost, wrinkled layer of our brains—contains a variety of brain areas that are connected to form neural networks.

It is well established that multiple brain areas are involved in generating movements, yet individual brain areas are often studied in isolation.

In general, our actions are not mere reflexes in response to external stimuli.

We all know that our thoughts change from moment to moment.

Imagine an autumn day.

Our motor systems are impressive.

How does the collective activity of individual neurons in the brain generate actions?

The essence of cognition is choice, and to understand choice we need to understand how neurons in the brain generate decisions in complex settings.

Imagine playing a game of catch.

All nervous systems must operate under conditions of uncertainty.

The way in which neurons process information determines how the brain functions.

Unaided by modern technology, our very survival would depend upon our brain’s ability to accurately map external space.

The brain is composed of billions of neurons, yet, until recently, technology only allowed for recording the electrical activity of a single neuron at a time.

The brain is composed of billions of neurons.

The neural substrates of memories and decisions.

The brain processes sensory stimuli and uses this information in conjunction with goals and memories to generate actions.

How the brain holds information in short-term memory is a mystery.

How does the brain give rise to the mind?

Consider the simple act of reaching for a cup of coffee.

Each time you look at a picture on a wall, even though you see the same thing, the electrical activity of neurons in your brain’s visual areas …

Imagine deciding whether or not to eat a piece of cake.

Decades of research have uncovered fundamental principles about how the eye works.

The cerebral cortex—the outermost, wrinkled layer of the brain—is involved in many cognitive processes, including sensory processing, decision-making, and movement.

Millions of neurons work together to produce perceptions, thoughts, and actions, but exactly how this happens remains a mystery.