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Homological mirror symmetry proof would relate seemingly disconnected mathematical realms

David Ginty shows that four different mice harboring mutations in ASD risk genes have altered peripheral sensory neuron processing that contributes to ASD-like phenotypes.

Through funding from the Simons Foundation and three other foundations, ASAPbio hopes to make preprints as popular among biologists as they are among physicists

Vera Sós is a Hungarian mathematician based at Eötvös Loránd University in Budapest. She specializes in number theory and combinatorics and has frequently collaborated with Paul Erdős, Alfréd …

Christian Luscher and Camilla Bellone show that ASD- model mice with reduced SHANK3 in the VTA have altered excitatory synapse transmission and impaired social behaviors.

This issue of the SFARI newsletter includes: (1) 2016 Bridge to Independence Award request for applications, (2) SFARI Blog: SFARI supports preprints for the life sciences, (3) Highlights …

At the edit-a-thons, get the chance to learn the basics of Wikipedia editing and make substantive changes to Wikipedia articles within your area of expertise

Dan Arking compares large-scale transcriptome datasets from neurotypical individuals and those with autism, schizophrenia and bipolar disorder.

Using fMRI in typically developing children, Vinod Menon finds one’s mother’s voice activates a network of brain regions predictive of a child’s social communication skills.

SFARI’s deputy scientific director, John Spiro, outlines two important changes that have been implemented in light of SFARI’s support for preprints of life science research findings …

… simple genetic and biochemical networks. In 2015, he received a Targeted Grant in the Mathematical Modeling of Living Systems from the Simons Foundation.

A research site in the Pacific that is essential to the Simons Collaboration on Ocean Processes and Ecology makes its mark on microbial oceanography

The Simons Foundation has named four winners of the 2016 Simons Early Career Investigator in Marine Microbial Ecology and Evolution Awards. The awards are intended to help launch …

… understand.) Importantly, this result relies on the proof of a new isoperimetric inequality in the Heisenberg group that is of independent interest to analysis and geometric measure …

Michael Wigler and Dan Levy develop a new fragmentation and sequencing method for CNV analysis that generates high-resolution CNV data at lower cost than traditional analyses.

A new facility to be built in Chile aims to uncover what happened in the instant after the Big Bang and answer other cosmological questions

Benjamin Philpot shows that seizure susceptibility in an Angelman syndrome mouse model results from the specific loss of UBE3A from GABAergic, but not glutamatergic, neurons.

Simons Center for Data Analysis scientist Richard Bonneau develops a method to assess disease gene variants that combines sequence analysis and protein structural modeling.

Guoping Feng and Michael Halassa create mice with global or thalamic-specific loss of the ASD-risk gene PTCHD1 to show specific roles for thalamic PTCHD1 in ASD …

How does the intense desire to know take shape in the brain? Simons Society Junior Fellow Jennifer Bussell is designing experiments to study that question

… to the enumerative geometry of curves and sheaves and the theory of random surfaces and random matrices. He was named a Simons Investigator in 2014. Steven R …

SFARI today announced the launch of SPARK, an online research initiative designed to become the largest autism study ever undertaken in the United States. SPARK will collect information …

This issue of the SFARI newsletter includes: (1) SFARI launches SPARK, an online research initiative that aims to recruit 50,000 individuals with autism, (2) Upcoming lecture: Christopher …

The initiative aims to recruit 50,000 individuals with autism to advance our understanding of the condition

… Collaboration on Cracking the Glass Problem, directed by Sidney Nagel of the University of Chicago. Simons Collaborations bring together groups of outstanding scientists to address mathematical or …

Mark Daly compares genetic data of social and communication difficulties in healthy individuals with ASD genetic data to show how risk variants lead to a behavioral continuum.

By comparing phenotypes in 25 individuals with de novo mutations in POGZ with SSC ASD phenotypic data, Evan Eichler uncovers a distinct POGZ-ASD clinical subtype.

SFARI is pleased to announce that it has selected six finalists in response to the Bridge to Independence Award request for applications. This new awards program is intended …

This issue of the SFARI newsletter includes: (1) SFARI announces Bridge to Independence Award finalists, (2) Exome sequencing data from the Simons Simplex Collection now available online, (3 …

Whole-exome sequencing and associated phenotypic data from the Simons Simplex Collection (SSC) are now accessible via WuXi NextCODE’s cloud-based database. This new platform allows researchers …

… related to autism spectrum disorders. Researchers may apply to WuXi NextCODE for access to the SSC dataset here.

… because we believe teachers know best what they need for their classrooms and students,” said MƒA President John Ewing. DonorsChoose.org is challenging the public to participate …

This question and others have come to the fore as advances in experimental neuroscience bring in data that challenge conventional wisdom

Dan Littman and colleagues use a mouse maternal immune activation (MIA) model to dissect immune pathways linking MIA with autism risk.

Using SHANK3 conditional knock-in mice, Guoping Feng shows that adult re-expression of SHANK3 improves cellular and behavioral abnormalities, including ASD-like deficits.

James Gusella and Michael Talkowski develop a CRISPR/CAS9 genomic method to generate microdeletions and microduplications in human iPSCs that mirror human CNV genetics.

SCGB investigators take center stage and discuss current thinking on a range of topics, including neural circuitry and theoretical principles of memory

Rather than rely on computational approximations, Ben Harrop-Griffiths of the Simons Society of Fellows uses a specific type of differential equation to understand the complex dynamics of …

Aditi Sheshadri of the Simons Society of Fellows looks at the fluid dynamics of the polar vortices and how they shape weather and climate

… a complete, collective unit. We want to understand whether it benefits their metastatic potential to stay as a collective unit.” Mugler’s vision for the next few …

The meeting will take place at the Simons Foundation, New York on Feb. 25-26, 2016. Please find further information here. The meeting will take place at the …

Evan Eichler compares whole-genome and whole exome sequencing data of ASD indivduals and finds an enrichment of variants in putative noncoding regulatory elements in ASD.

The Autism Inpatient Collection, directed by Matthew Siegel, enrolls individuals severely affected by autism, facilitating assessment of this under-represented group.

Irving Reti assesses, in two ASD mouse models, the utility of targeted, subthalamic nucleus, deep brain stimulation to treat severe forms of self-injurious behavior.