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Bringing people and ideas together to fund, conduct, and share transformative science.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    October 25, 2019
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  2. Watch: How SCOPE Discovers the Secret Life of Ocean Microbes

    October 24, 2019
    David Karl and Ed DeLong, directors of the Simons Collaboration on Ocean Processes and Ecology, describe the importance of understanding the organisms at the base of the marine …
  3. CCQ Director Antoine Georges Awarded Rahman Prize for Computational Physics

    October 22, 2019
    The American Physical Society has awarded its 2020 Aneesur Rahman Prize for Computational Physics to Antoine Georges. He shares the prize with Gabriel Kotliar of Rutgers University. Georges …
  4. Q&A: The Battle Between Learning and Memory

    October 18, 2019
    Yael Niv explores how the brain represents the structure of the world — and how it organizes these representations so that we can most effectively learn from past experiences …
  5. Fireworks, Apple Pie and Robots

    October 17, 2019
    A high schooler and his robotics teammates create a lunar rover replica for a small town Fourth of July parade
  6. The Data-Sharing Problem in Neuroscience

    October 4, 2019
    When it comes to data sharing, neuroscience lags behind many other fields. But a growing number of large-scale projects are inspiring new efforts to develop workable tools.
  7. Standardizing Data Across Species: A Case Study

    October 4, 2019
    A multilab collaboration at the University of Washington is developing ways to compare data from humans and monkeys.
  8. How BrainCogs Learned to Share: A Case Study

    October 4, 2019
    Members of the multi-lab BrainCogs collaboration are using DataJoint to more easily access each other’s data.
  9. Taming the Wild Data World of Neuroscience

    October 3, 2019
    Driven by the growing number of large-scale collaborations, researchers are developing new ways to standardize both data and analysis pipelines.
  10. Why Neurophysiology Needs an MP3

    October 2, 2019
    When it comes to data sharing, neuroscience lags behind many other fields. But a growing number of large-scale projects are inspiring new efforts to develop workable tools.
  11. International Collaborations Face Increasing Hurdles

    October 2, 2019
    Policy changes in various countries have put scientists and their collaborative nature under scrutiny, threatening academic freedom and student enrollment.
  12. ASHG 2019: Presentations by SFARI Investigators and Collaborators

    October 1, 2019
    A number of SFARI Investigators, collaborators and Simons Foundation scientists will present their latest research findings related to the genomic and transcriptomic architecture of autism spectrum disorder and …
  13. SFARI Summer 2019 Pilot Awardees Announced

    September 30, 2019
    SFARI is pleased to announce that is intends to fund 12 grants in response to the Summer 2019 Pilot Award request for applications.
  14. Targeting Somatosensory Over-Reactivity in Mouse Models of ASD

    September 30, 2019
    David Ginty and colleagues have identified mechanisms through which peripheral loss of ASD-associated genes affect behaviors in mice and identify a potential peripherally restricted therapy to treat …
  15. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    September 30, 2019
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  16. Predicting Aggression With Wearable Biosensors

    September 30, 2019
    Matthew Goodwin, Matthew Siegel and colleagues found that data from a wearable biosensor can be used to accurately predict aggressive behavior up to one minute before it occurs.
  17. Aberrant Neocortical Connectivity in Shank3 Mutant Mice

    September 27, 2019
    Alessandro Gozzi and colleagues found that Shank3-deficient mice have disrupted frontocortical functional connectivity, which is associated with impaired communication and social behaviors.
  18. SFN 2019 Presentations by SCGB Investigators, Fellows and Collaborators

    September 27, 2019
    Traveling to the annual meeting in Chicago? Check out these talks.
  19. Neuroscience 2019: Presentations by SFARI Investigators

    September 27, 2019
    SFARI Investigators will give a number of presentations at Neuroscience 2019 in Chicago, IL (October 19–23).
  20. ‘Ringing’ Black Hole Validates Einstein’s General Relativity 10 Years Ahead of Schedule

    September 12, 2019
    Gravitational wave ‘tones’ detected following the merger of two black holes confirm the decades-old ‘no-hair theory’ of black hole properties.
  21. Simons Investigator Alex Eskin Awarded Breakthrough Prize in Mathematics

    September 11, 2019
    The mathematician is recognized for his many contributions, including the proof of the ‘magic wand theorem’
  22. SPARK Pilot Study Identifies Novel Candidate Autism Risk Genes

    September 3, 2019
    Findings from the first SPARK genetics study have now been published. The study, which analyzed whole-exome and genome-wide genotyping data from 457 autism families, confirmed known …
  23. Mystery Solved About the Machines That Move Your Genes

    September 2, 2019
    Congestion causes the mass of tubes and motors that form chromosome-dividing spindles to move at full speed instead of slowing to a crawl, new research reveals.
  24. Simons Searchlight: New Data Release

    August 28, 2019
    New Simons Searchlight data were recently added to SFARI Base. This data release included phenotypic data from individuals with 16p11.2 copy number variants (CNVs), 1q21.1 CNVs …
  25. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    August 26, 2019
    Each month, SCGB scans the bioRxiv for interesting papers from the SCGB community and beyond.
  26. Q&A: Finding Structure in Neural Activity

    August 26, 2019
    New technologies for tracking hundreds of neurons simultaneously provide new ground for testing decades-old theories, explains the SCGB’s Ila Fiete of MIT.
  27. Simons VIP Rebranded As Simons Searchlight

    August 23, 2019
    The Simons Variation in Individuals Project (Simons VIP) has been recently rebranded as Simons Searchlight. The new name aims to better reflect the program’s mission to build …
  28. Revealing the Invisible Wildlife of New York City

    August 22, 2019
    Microbiologist Sally Warring aims to uncover the millions of tiny organisms lurking just beneath the surface of the city’s waters.
  29. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    August 19, 2019
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  30. Simons Investigator Steven Gubser (1972–2019)

    August 9, 2019
    … broken new ground on the connections between theoretical models of black holes and the real-world many-body systems, such as the quark-gluon plasma produced at …
  31. Sundance, Science Sandbox Announce Nine New Grant Recipients

    August 1, 2019
    Following a successful first year, the partnership has expanded to provide increased funding for emerging voices in science storytelling
  32. Searching for the Hidden Factors Underlying the Neural Code

    July 31, 2019
    Three new methods to identify hidden structure in neural activity.
  33. Workshop Plumbs Infancy for Autism Insights

    July 30, 2019
    On April 18, 2019, SFARI brought together autism specialists and child development experts to explore the short-lived yet critical period of infancy. Understanding how cognition, motor skills …
  34. A Stellar Stream in the Milky Way Provides Evidence of Dark Substructure

    July 29, 2019
    Scientists observe unexplained behavior in the GD-1 stellar stream, begin search for clumps of dark matter in the Milky Way.
  35. Frustrated Fish Reveal Glia’s Computational Role in Motivated Behavior

    July 29, 2019
    New research shows that a population of astrocytes in fish keeps track of failed attempts to swim and signals when to give up.
  36. Unexpected Synaptic Role for the Autism Risk Gene Scn2a

    July 26, 2019
    Kevin Bender, Stephan Sanders and colleagues show that there is an unexpectedly critical role for the autism risk gene Scn2a, which encodes the sodium channel NaV1.2, in …
  37. A Pipeline for Functional Assessment of Autism-Associated Missense Mutations in C. Elegans

    July 24, 2019
    Paul Sternberg and colleagues establish an initial pipeline in C. elegans to screen autism-associated missense mutations for functional effects.
  38. Distinct Patterns of Connectivity Underlie Differences in Sensory Responsiveness in Autism

    July 24, 2019
    Susan Bookheimer and colleagues show that the degree of sensory overresponsivity in individuals with autism may be driven by distinct patterns of connectivity between the prefrontal cortex and …
  39. Watch: Computer Scientist Constantinos Daskalakis on Tackling High-Dimensional Data

    July 24, 2019
    The 2018 Nevanlinna Prize winner describes his interest in economics, statistics, machine learning and the application of game theory in raising children.
  40. A Conversation With SFARI Investigator Dan Feldman

    July 23, 2019
    SFARI Investigator Dan Feldman discusses the E-I ratio hypothesis in autism and his lab’s recent studies that aimed to test it.
  41. A Mouse Model of 22q11.2 Deletion Syndrome Shows Reduced Long-Range Connectivity and Dysfunctional Mitochondria

    July 12, 2019
    Anthony-Samuel LaMantia, Thomas Maynard and colleagues show that a mouse model of 22q11.2 deletion syndrome has fewer long-distance cortico-cortical connections, which is caused in …
  42. Two Studies Using SPARK’s Research Matching Program Attest to Its Effectiveness for Rapid and Large-Scale Testing of Research Questions

    July 12, 2019
    Two studies from Brigitta Monz, Richard Houghton and colleagues provide examples of the effectiveness of SPARK’s research match program to rapidly recruit thousands of individuals for the …
  43. Brief Treatment With Statin Yields Long-Term Benefit in Rat Model of Fragile X Syndrome

    July 12, 2019
    Peter Kind and colleagues show that brief treatment with lovastatin results in sustained correction of physiological and behavioral deficits in a rat model of fragile X syndrome.
  44. Single-Nucleus RNA Sequencing Identifies Brain Cell Types With Significant Changes in Gene Expression in Autism

    July 10, 2019
    Using single-nucleus RNA sequencing of postmortem cortical tissue from individuals with ASD, Arnold Kriegstein and colleagues identify upper-layer excitatory neurons and microglia as key cell types …
  45. Watch: Maarten de Hoop Turns the Earth Inside Out

    July 10, 2019
    Maarten de Hoop of Rice University explores the foundations of seismic waves to better understand what’s going on inside our planet.
  46. Pair of Supermassive Black Holes Discovered on a Collision Course

    July 10, 2019
    The titanic duo can help astronomers predict when the historic first detection of the background ‘hum’ of gravitational waves from supermassive black holes will be made and whether …
  47. SFARI Gene: New Data Release

    July 8, 2019
    New data were recently added to SFARI Gene. This data release included the addition of new genes and copy number variant loci associated with autism. New mouse and …
  48. Substantial Role for Biallelic Mutations in Autism Risk, Particularly in Females

    July 3, 2019
    Timothy Yu and colleagues analyzed exome sequencing data to estimate that recessive mutations contribute to approximately 5 percent of all cases of autism, including 10 percent of females.
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