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Leveraging personalized genomics can aid the development of effective autism therapies, promising new research suggests. -
Alex Kwan and colleagues used in vivo calcium imaging to show that a mutation in Shank3 associated with schizophrenia affects the activity of inhibitory neurons in the cortex … -
New data were added to SFARI Gene in April 2020. This data release included the addition of new candidate autism risk genes, new curated references of copy number … -
Phenotypic data from 230,936 participants enrolled in SPARK, including more than 90,000 individuals with ASD, are now available to approved researchers. -
Catharine Rankin, Kurt Haas, Paul Pavlidis and colleagues used machine vision to find that mutations linked to ASD risk genes are associated with changes in habituation of response … -
David Sulzer and colleagues used conditional knockout mice of Atg7, a protein involved in autophagy, to study the effects of loss of autophagy on the structure and function … -
Genetic Mutations Linked to Kleefstra Syndrome Converge on Similar Neuronal Hyperactivity Phenotypes
Nael Nadif Kasri and colleagues used micro-electrode array assays to demonstrate common neuronal network phenotypes associated with genes underlying Kleefstra spectrum syndrome. -
… Investigator, Simons Collaboration on Principles of Microbial Ecosystems. Jacob Lurie Institute for Advanced Study. 2018 Simons Fellow in Mathematics. Gregory Moore Rutgers, the State University of New … -
Genetic dark matter makes up 98 percent of our genomes, yet scientists are still figuring out how it works. -
Seven researchers supported by the Simons Foundation and board member Margaret Hamburg are among the latest group of prominent artists, scholars, scientists and leaders elected as fellows of … -
Despite numerous breakthroughs into the causes of autism, many mysteries about the condition remain. -
The Columbia University neuroscientist, who won a Nobel Prize for his work on memory, explains why the biology of the mind continues to fascinate him. -
SFARI reminds all approved Principal Investigators that the use of data sets and/or biospecimens obtained from the SFARI Simons Collection is subject to certain limitations and that … -
SFARI Investigator Karen Parker discusses her preclinical and clinical research on the neuropeptides arginine vasopressin and oxytocin as potential biomarkers and treatment strategies for autism spectrum disorder. -
SFARI is pleased to announce that it intends to fund 11 grants in response to the Winter 2020 Pilot Award request for applications. -
Joseph Gleeson and colleagues used deep whole-genome sequencing and genotyping of sperm DNA to stratify ASD risk in offspring due to de novo mutation. -
Ofer Yizhar and colleagues described the altered dynamics of social representation in neurons of the medial prefrontal cortex of Cntnap2-null mice, a model of autism spectrum disorder. -
SFARI is writing to assure you that the health and well-being of your lab members is very much in our minds during the COVID-19 epidemic. We … -
Gloria Choi, Jun Huh and colleagues showed that postnatal administration of IL-17a can rescue some of the anatomical and behavioral deficits observed in a maternal immune activation … -
SFARI is pleased to announce that 10 Director Awards were awarded in 2019. These projects include, but are not limited to, studies that aim to enhance existing SFARI … -
To speed discovery, SFARI decided to break the traditional approach in which each laboratory collects its own datasets and keeps them close to the vest. -
On June 22, 2019, families of people with DYRK1A syndrome gathered in Seattle to support one another and meet with researchers. A rare condition resulting from mutations to … -
We asked the foundation’s distinguished scientist, who joined us in 2006 to lead the Simons Foundation Autism Research Initiative (SFARI), to reflect on the initiative and its … -
SFARI has recently implemented a number of changes to SFARI Gene, including modification of the gene scoring, copy number variant, animal models and protein interaction modules. Curation of … -
Michael Halassa, Guoping Feng and colleagues identified a combinatorial strategy to reverse noise hypersensitivity in Ptchd1 knockout mice, while Stephen Scherer, James Ellis and colleagues separately explored the … -
Mark Daly and colleagues used an exome sequencing data set of ASD and ADHD to identify a similar profile of rare protein-truncating variants in each disorder. -
The push to gain a deep understanding of the genetics and neurobiology of autism has forced scientists to reexamine three ideas about the condition. -
On August 2–3, 2019, people from around the world met in Seattle, Washington, to review recent findings about mutations to the sodium channel encoded by SCN2A. Organized … -
A study from Matthew Anderson and colleagues identified an excess of T-lymphocytes in the postmortem ASD brain, which are prominently associated with astrocytes. -
Cerebral fascinations: We asked our neuroscientists why they find the brain beautiful. -
SFARI announces that it has selected five fellows in response to the 2019 Bridge to Independence Award request for applications. -
On May 21, 2019, the recipients of the SFARI Bridge to Independence Award gathered at the Simons Foundation to discuss their scientific findings and plans in autism research. -
Funds donated by SFARI to Gordon Research Conferences will now be allocated to support attendance of eligible early-career (pre-tenure) women, early-career trainees from historically underrepresented … -
SFARI is now curating a set of zebrafish lines to study autism spectrum disorder. This includes mutant lines for 12 ASD risk genes, four of which are currently … -
SFARI director Louis Reichardt will leave SFARI this coming October. -
SFARI held its 15th science meeting April 7–9, 2019. Over 100 SFARI investigators, collaborators and foundation staff convened to discuss recent findings on the genetics, molecular- and … -
In this blog post, Paul Wang discusses the importance of supporting the development and validation of objective clinical outcome measures for autism. He also provides an overview of … -
SFARI has awarded four grants in response to the 2019 Novel Outcome Measures in Autism Spectrum Disorder (ASD) request for applications. These grants will support the development and … -
Caroline Robertson and colleagues developed a novel paradigm that provided direct neural evidence for slower binocular rivalry in autism. They also demonstrated a causal link between GABAergic inhibition … -
A uniform call-set of joint variant calls, including single-nucleotide variants and indels, for 9,209 samples with whole-genome sequencing data from the Simons Simplex Collection … -
Three recent studies – two by Kristopher Kahle and Igor Medina, and the third by Xin Tang, Mriganka Sur and Rudolf Jaenisch – explored regulatory mechanisms that modulate KCC2 function … -
Daniel Geschwind, Michael Gandal and colleagues reported that allelic imbalance in gene expression in ASD shows a surprising preference for the minor allele and implicates a family of … -
Six current and past SFARI Investigators were among the 100 newly elected members of the National Academy of Medicine. -
In this blog post, Wendy Chung and John Spiro outline some of the important ways in which the Simons Searchlight program has been recently expanded, including increasing the … -
A number of SFARI Investigators, collaborators and Simons Foundation scientists will present their latest research findings related to the genomic and transcriptomic architecture of autism spectrum disorder and … -
SFARI is pleased to announce that is intends to fund 12 grants in response to the Summer 2019 Pilot Award request for applications. -
David Ginty and colleagues have identified mechanisms through which peripheral loss of ASD-associated genes affect behaviors in mice and identify a potential peripherally restricted therapy to treat … -
Matthew Goodwin, Matthew Siegel and colleagues found that data from a wearable biosensor can be used to accurately predict aggressive behavior up to one minute before it occurs.