Saul Villeda, Ph.D.Assistant Professor, Department of Anatomy; Associate Director, Bakar Aging Research Institute, University of California, San Francisco
Simons Foundation Lectures are free public colloquia related to basic science and mathematics. These high-level talks are intended for professors, students, postdocs and business professionals, but interested people from the metropolitan area are welcome as well.
Aging drives cognitive impairments in the adult brain. It is imperative to gain insight into what drives aging phenotypes in the brain to maintain and even restore functional integrity in the elderly.
In this lecture, Saul Villeda will talk about how he and others have shown that systemic manipulations — such as heterochronic parabiosis (in which a young and old circulatory system are joined) and administration of young blood plasma — can reverse age-related impairments in regenerative and synaptic processes. Such manipulations can also rescue cognitive faculties in the aged brain. More recently, his lab demonstrated that administration of exercise-induced blood factors can likewise partially reverse age-related loss of plasticity in the aged brain. Consequently, scientists can now consider reactivating latent plasticity dormant in the aged brain to rejuvenate regenerative, synaptic and cognitive functions late in life. His research program aims to elucidate cellular and molecular mechanisms that can be targeted to halt the aging process or promote rejuvenation in the old brain. Understanding how to reverse aging in the brain could enable us to sidestep the effects of aging that promote vulnerability to neurodegenerative diseases altogether, providing a unique therapeutic approach.
Registration is required for this free event.
Further instructions and access to join the webinar will be sent to all registrants upon sign up.