The Center for Computational Biology develops new and innovative methods of examining data in the biological sciences whose scale and complexity have historically resisted analysis.
Featured News
Center for Computational Biology
Unexpected Forces Cause Rotor Proteins to Self-Organize
Read More
A model system exploring ATP synthase reveals that rotation, repulsion and flow can crystallize proteins. It may explain a biophysical mystery in mitochondrial membranes.
CCB’s mission is to develop modeling tools and theory for understanding biological processes and to create computational frameworks that will enable the analysis of the large, complex data sets being generated by new experimental technologies.
Groups
Collaborative Work
Structural and Molecular Biophysics Collaboration
Underlying all biological processes are molecules and their interactions with each other. However, our ability to understand how these molecules function over biologically relevant scales remains very limited.
- CCB
- CCM
Upcoming Events
-
27 Mon -
Meeting 10:00 a.m. - 12:00 p.m.
Biophysical Modeling Group Meeting
-
Meeting 10:00 - 11:00 a.m.
Developmental Dynamics Group Meeting
-
Meeting 2:00 - 3:00 p.m.
Electron Microscopy Interest Group Meeting
-
Meeting 10:00 a.m. - 12:00 p.m.
-
28 Tue -
30 Thu -
Meeting 10:00 - 11:00 a.m.
CCB Seminar: Weight loss dependent and independent effects of bariatric surgery (Danny Beh-Ziv, Hebrew University of Jersualem)
-
Meeting 11:30 a.m. - 1:30 p.m.
Genomics Group Meeting
-
Meeting 10:00 - 11:00 a.m.
-
07 Thu -
Meeting 11:30 a.m. - 1:30 p.m.
Genomics Group Meeting
-
Meeting 11:30 a.m. - 1:30 p.m.
-
11 Mon -
Meeting 10:00 a.m. - 12:00 p.m.
Biophysical Modeling Group Meeting
-
Meeting 10:00 - 11:00 a.m.
Developmental Dynamics Group Meeting
-
Meeting 10:00 a.m. - 12:00 p.m.
Publication Highlights
Sequence-structure-function relationships in the microbial protein universe
For the past half-century, structural biologists relied on the notion that similar protein sequences give rise to similar structures and…
bioRxivDeconstructing gastrulation at single-cell resolution
T. Stern, S. Shvartsman, E. F. Wieschaus
Gastrulation movements in all animal embryos start with regulated deformations of patterned epithelial sheets, which are driven by cell divisions,…
Current BiologyThermodynamically consistent coarse-graining of polar active fluids
Scott Weady, D. Stein, M. Shelley
We introduce a closure model for coarse-grained kinetic theories of polar active fluids. Based on a thermodynamically consistent, quasi-equilibrium approximation…
arXivDirector
Software
aLENS
This is the simulation tool for tracking assemblies of microtubules driven by motor proteins.
STKFMM
This is a numerical computation package for various single- and double-layer kernels for Laplace and Stokes operators in boundary integral methods, implemented on top of the highly-optimized kernel independent fast-multipole method package PVFMM.
humanbase
Data-driven predictions of gene expression, function, regulation, and interactions in human.
DeepSEA
Deep learning-based algorithmic framework for predicting chromatin effects
FNTM
Functional Networks of Tissues in Mouse
GIANT
Genome-wide Scale functional interaction networks for 144 human tissues and cell types
IMP 2.0
Integrative Multi-species Prediction
KNNimpute
K-Nearest Neighbors Imputation
Nano-Dissection
This server performs in silico nano-dissection, an approach we developed to identify genes with novel cell-lineage specific expression.
SEEK
Search-Based Exploration of Expression Compendium [Human]
Sleipnir
Sleipnir Library for Computational Functional Genomics
URSA(HD)
A data-driven perspective to your gene expression profile for human tissues and diseases.