Center for Computational Biology

Featured News

Center for Computational Biology Finding Signals in the Noise with HumanBase By Susan Reslewic Keatley, Ph.D.

This powerful, dynamic software system is changing how scientists sift through the recent deluge of human genomic data — and deepening our knowledge of human biology, health and disease.

The Center for Computational Biology develops new and innovative methods of examining data in the biological sciences whose scale and complexity have historically resisted analysis.

CCB’s mission is to develop modeling tools and theory for understanding biological processes and to create computational frameworks that will enable the analysis of the large, complex data sets being generated by new experimental technologies.

Groups

Biophysical Modeling The Biophysical Modeling group focuses on the modeling and simulation of complex systems that arise in biology and soft condensed matter physics. Read More

Developmental Dynamics The Developmental Dynamics group combines experiments, theory and computing to elucidate the contributions of encoded genomic instructions and self-organizing physical mechanisms to embryonic development. Read More

Genomics An immensely complex molecular network of interactions forms the foundation of human biology and disease. Genomic approaches provide a particularly illuminating window to biological systems, and when combined with advanced analysis allow us to learn and model this complexity. Read More

Structural and Molecular Biophysics Collaboration Underlying all biological processes are molecules and their interactions with each other. However, our ability to understand how these molecules function over biologically relevant scales remains very limited. Read More

Systems Biology At the Systems Biology group, we are developing new methods to learn the networks that run life’s program. Read More

News & Announcements

February 04, 2021

CCB and CCM Collaborate to Create the New Structural and Molecular Biophysics Team

January 13, 2021

Mathematics Explains How Giant Whirlpools Form in Developing Egg Cells By Thomas Sumner

December 01, 2020

Unveiling the Forces Behind Millions of Years of Cell Division By Susan Reslewic Keatley, Ph.D.

Upcoming Events

March 2021

01 Mon
- Seminar 8:00 AM - 5:00 PM
  Biophysics and Development Seminar Series
- Meeting 10:00 - 11:00 AM
  Systems Biology Group Meeting
02 Tue
- Meeting 5:00 - 6:00 PM
  DevDy Group Meeting
04 Thu
- Meeting 1:00 - 2:00 PM
  Genomics Group Meeting
05 Fri
- Meeting 2:00 - 3:00 PM
  Drosophila Journal Club
08 Mon
- Meeting 10:00 - 11:00 AM
  Systems Biology Group Meeting
- Lecture 1:00 - 2:00 PM
  Biophysics & Development Seminar: Gregory Voth, University of Chicago
11 Thu
- Meeting 1:00 - 2:00 PM
  Genomics Group Meeting
15 Mon
- Meeting 10:00 - 11:00 AM
  Systems Biology Group Meeting
16 Tue
- Meeting 5:00 - 6:00 PM
  DevDy Group Meeting

Research Highlights

February 8, 2021

Mapping parameter spaces of biological switches

R. Diegmiller, L. Zhang, M. Gamiero, J. Barr, J. Alsous, P. Schedl, S. Shvartsman, K. Mischaikow

Since the seminal 1961 paper of Monod and Jacob, mathematical models of biomolecular circuits have guided our understanding of cell…

PLoS Computational Biology

February 5, 2021

Chiral crystals self-knead into whorls

E. Bililign, F. Balboa Usabiaga, Y. Ganan, V. Soni, S. Magkiriadou, M. Shelley, D. Bartolo, W. Irvine

The competition between thermal fluctuations and potential forces is the foundation of our understanding of phase transitions and matter in…

arXiv:2102.03263

January 25, 2021

mRNA-1273 efficacy in a severe COVID-19 model: attenuated activation of pulmonary immune cells after challenge

M. Meyer, Y. Wang, D. Edwards, G. Smith, A. Rubenstein, P. Ramanathan, C. Mire, C. Pietzch, X. Chen, Y. Ge, W. Cheng, C. Henry, A. Woods, L. Ma, G. Stewart-Jones, K. Bock, M. Minai, B. Nagata, S. Periasamy, P. Shi, B. Graham, I. Moore, I. Ramos, O. Troyanskaya, E. Zaslavsky, A. Carfi, S. Sealfon, A. Bukreyev

The mRNA-1273 vaccine was recently determined to be effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from interim Phase…

bioRxiv 2021.01.25.428136

Director

Michael Shelley, Ph.D.

Director, CCB

Michael Shelley joined the Simons Foundation in 2016 to work on the modeling and simulation of complex systems arising in physics and biology.

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