The Center for Computational Biology develops new and innovative methods of examining data in the biological sciences whose scale and complexity have historically resisted analysis.
Featured News
Center for Computational Biology
New Model Predicts How Bacteria Navigate Obstacles to Spread
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A Flatiron Institute scientist has developed the first analytical model for predicting how bacteria spread in environments filled with obstacles. This model will help inform strategies for curbing bacterial infections or for designing better drug delivery devices.
CCB’s mission is to develop modeling tools and theory for understanding biological processes and to create computational frameworks that will enable the analysis of the large, complex data sets being generated by new experimental technologies.
Research Areas
Collaborative Work
Structural and Molecular Biophysics
Underlying all biological processes are molecules and their interactions with each other. However, our ability to understand how these molecules function over biologically relevant scales remains very limited.
- CCB
- CCM
CCBx
The Center for Computational Biologyx (CCBx) is an effort by the Center for Computational Biology (CCB) to (a) create and validate quantitative techniques and (b) develop and test theories of biological systems that are predictive of these systems’ behaviors and responses to genetic, chemical and physical perturbations.
- CCB
Upcoming Events
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22 Tue -
Meeting 9:45 - 11:00 a.m.
Biophysical Modeling Group Meeting
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Meeting 11:30 a.m. - 1:30 p.m.
Genomics Group Meeting
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Meeting 2:00 - 3:00 p.m.
Structural & Molecular Biophysics Group Meeting
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Meeting 9:45 - 11:00 a.m.
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24 Thu -
Seminar 11:00 a.m. - 12:00 p.m.
CCB Seminar: William Jacobs, Ph.D.
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Seminar 11:00 a.m. - 12:00 p.m.
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28 Mon -
Meeting 10:30 a.m. - 12:00 p.m.
Developmental Dynamics Group Meeting
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Meeting 10:30 a.m. - 12:00 p.m.
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29 Tue -
Meeting 9:45 - 11:00 a.m.
Biophysical Modeling Group Meeting
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Meeting 2:00 - 3:00 p.m.
Structural & Molecular Biophysics Group Meeting
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Meeting 9:45 - 11:00 a.m.
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30 Wed -
Meeting 1:30 - 3:30 p.m.
Genomics Group Meeting
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Meeting 1:30 - 3:30 p.m.
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29 Thu -
Colloquium 11:00 - 11:00 a.m.
CCB Colloquium: John Toner, Ph.D.
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Colloquium 11:00 - 11:00 a.m.
Publication Highlights
Geometric model for dynamics of motor-driven centrosomal asters
Yuan-Nan Young, Vicente Gomez Herrera, Huan Zhang, R. Farhadifar, M. Shelley
The centrosomal aster is a mobile and adaptable cellular organelle that exerts and transmits forces necessary for tasks such as…
Physical Review ResearchThe 2024 New York City Integrative Structural Biology Symposium
P. Cossio, Edward T. Eng
The 2024 New York City Integrative Structural Biology Symposium focused on understanding the challenges and opportunities of applying integrative structural…
Trends in Pharmacological SciencesBiomolecular condensates control and are defined by RNA-RNA interactions that arise in viral replication
Dilimulati Aierken, Vita Zhang, R. Sealfon, et al.
Cells must limit RNA–RNA interactions to avoid irreversible RNA entanglement. Cells may prevent deleterious RNA-RNA interactions by genome organization to…
bioRxivDirector
Software
aLENS
This is the simulation tool for tracking assemblies of microtubules driven by motor proteins.
STKFMM
This is a numerical computation package for various single- and double-layer kernels for Laplace and Stokes operators in boundary integral methods, implemented on top of the highly-optimized kernel independent fast-multipole method package PVFMM.
humanbase
Data-driven predictions of gene expression, function, regulation, and interactions in human.
DeepSEA
Deep learning-based algorithmic framework for predicting chromatin effects
FNTM
Functional Networks of Tissues in Mouse
GIANT
Genome-wide Scale functional interaction networks for 144 human tissues and cell types
IMP 2.0
Integrative Multi-species Prediction
KNNimpute
K-Nearest Neighbors Imputation
Nano-Dissection
This server performs in silico nano-dissection, an approach we developed to identify genes with novel cell-lineage specific expression.
SEEK
Search-Based Exploration of Expression Compendium [Human]
SkellySim
SkellySim is a simulation package for simulating cellular components such as flexible filaments, motor proteins, and arbitrary rigid bodies.
Sleipnir
Sleipnir Library for Computational Functional Genomics
URSA(HD)
A data-driven perspective to your gene expression profile for human tissues and diseases.