Plasticity and the Aging Brain
The Simons Collaboration on Plasticity and the Aging Brain aims to discover mechanisms of resilience and maintenance in the aging brain and to establish a baseline for age-related changes in plasticity across many model systems, in order to identify potential interventions to minimize cognitive decline and extend healthy lifespan.
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Related Gordon Conference Biology of Aging
While the biology of aging is still a relatively new field, this GRC has become the premier forum for unpublished data presentation and discussions, resulting in a meeting where one can view exciting current science and also see the future directions of the field. Applications for this meeting must be submitted by June 4, 2023.
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Research Highlights
Ageing and rejuvenation of tissue stem cells and their niches
Most adult organs contain regenerative stem cells, often organized in specific niches. Stem cell function is critical for tissue homeostasis…
Nat Rev Mol Cell BiolPeriarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer’s disease
Perivascular spaces (PVS) drain brain waste metabolites, but their specific flow paths are debated. Meningeal pia mater reportedly forms the…
Nat CommunHigh-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity
Mitochondrial dysfunction is a well-known contributor to aging and age-related diseases. The precise mechanisms through which mitochondria impact human lifespan,…
Geroscience