Plasticity and the Aging Brain
The Simons Collaboration on Plasticity and the Aging Brain aims to discover mechanisms of resilience and maintenance in the aging brain and to establish a baseline for age-related changes in plasticity across many model systems, in order to identify potential interventions to minimize cognitive decline and extend healthy lifespan.
Events & Lectures
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Related The Reproductive Aging Conference
This will be the first ever international meeting dedicated entirely to the mechanisms of reproductive aging, with a goal to showcase research and stimulate collaborations that bridge the disciplines of reproductive biology and aging research to help define new paradigms to accelerate research in this area of biology. Abstract deadline: April 25, 2022. Registration closing deadline: June 1, 2022.
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Related Metabolism, Aging, Pathogenesis, and Stress in C. elegans
The 2022 C. elegans “Topics” Meeting “Metabolism, Aging, Pathogenesis, and Stress” (MAPS 2022), on campus at the University of Wisconsin-Madison, Memorial Union will host researchers studying fundamental questions regarding increasing health-span and reducing aging-associated decline.
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Related Mechanisms of Aging
The meeting will explore the regulation and function of genes and processes that are now known or suspected to control cellular and/or organismic aging. Abstract Deadline: July 8, 2022
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Related Gordon Conference Biology of Aging
While the biology of aging is still a relatively new field, this GRC has become the premier forum for unpublished data presentation and discussions, resulting in a meeting where one can view exciting current science and also see the future directions of the field. Applications for this meeting must be submitted by June 4, 2023.
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Research Highlights
Limited proteolysis–mass spectrometry reveals aging-associated changes in cerebrospinal fluid protein abundances and structures
Cerebrospinal fluid (CSF) proteins and their structures have been implicated in aging and neurodegenerative diseases. In the present study, we…
Nature AgingKL1 Domain of Longevity Factor Klotho Mimics the Metabolome of Cognitive Stimulation and Enhances Cognition in Young and Aging Mice
Cognitive deficits are a major biomedical challenge-and engagement of the brain in stimulating tasks improves cognition in aged individuals (Wilson…
J NeurosciSmall molecule C381 targets the lysosome to reduce inflammation and ameliorate disease in models of neurodegeneration
SignificanceNeurodegenerative diseases are poorly understood and difficult to treat. One common hallmark is lysosomal dysfunction leading to the accumulation of…
Proc Natl Acad Sci U S A