Our theoretical and computational work is designed to integrate and abstract rapidly accumulating heterogeneous datasets, to propose critical tests of multiscale regulatory mechanisms, and to guide our own genetic and imaging experiments. Our research is organized around three main themes: the mechanistic modeling of pattern formation and morphogenesis; the synthesis and decomposition of developmental trajectories; and the modeling of human developmental defects. Current projects focus on small cell clusters (motivated by our work on early embryos and animal germline development), graph dynamics in rearranging cell networks (motivated by problems of epithelial morphogenesis), and the effects of activating mutations in signaling enzymes (motivated by our work on a large class of human developmental abnormalities).
The rupture potential of an atherosclerotic plaque is dependent on both the plaque’s composition and the shear stresses it encounters…
IEEE International Ultrasonics SymposiumThe cell nucleus is enveloped by a complex membrane, whose wrinkling has been implicated in disease and cellular aging. The…
arXiv: 1704.03884Numerous engineered and natural systems form through reinforcement and stabilization of a deformed configuration that was generated by a transient…
Biophysical Journal
