Nuclear instance segmentation and tracking for preimplantation mouse embryos
For investigations into fate specification and cell rearrangements in live images of preimplantation embryos, automated and accurate 3D instance segmentation…
bioRxivOur theoretical and computational work is designed to integrate and abstract rapidly accumulating heterogeneous datasets, to propose critical tests of multiscale regulatory mechanisms, and to guide our own genetic and imaging experiments. Our research is organized around three main themes: the mechanistic modeling of pattern formation and morphogenesis; the synthesis and decomposition of developmental trajectories; and the modeling of human developmental defects. Current projects focus on small cell clusters (motivated by our work on early embryos and animal germline development), graph dynamics in rearranging cell networks (motivated by problems of epithelial morphogenesis), and the effects of activating mutations in signaling enzymes (motivated by our work on a large class of human developmental abnormalities).
For investigations into fate specification and cell rearrangements in live images of preimplantation embryos, automated and accurate 3D instance segmentation…
bioRxivThe decision to stop growing and mature into an adult is a critical point in development that determines adult body…
Applied MathematicsDuring vertebrate organ morphogenesis, large collectives of cells robustly self-organize to form architectural units (bones, villi, follicles) whose form persists…
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