Richard Bonneau, Ph.D.Vice President, Machine Learning Drug Discovery, Genentech, Inc.
Presidential Lectures are free public colloquia centered on four main themes: Biology, Physics, Mathematics and Computer Science, and Neuroscience and Autism Science. These curated, high-level scientific talks feature leading scientists and mathematicians and are intended to foster discourse and drive discovery among the broader NYC-area research community. We invite those interested in the topic to join us for this weekly lecture series.
We can think about biodiversity from an evolutionary and organismal perspective, cataloging and modeling biodiversity of interacting species. Another useful way to think about biodiversity is to think of the diversity of biological sequences and structures. Multiple large-scale public and private efforts have sequenced, using automated DNA sequencing technology, a vast number of genomes and fragments of genomes that span the tree of life. Within those genomes are sequences that code for a very large assortment of molecular structures (RNA and protein structures) and functions (everything from catalysts to proteins that process cellular information).
In this Presidential Lecture, Richard Bonneau will discuss new machine-learning methods for characterizing these biomolecules. He will discuss how these methods lead to methods for designing new molecules not seen before in nature. The methods presented will lie at the intersection of modeling the physics of protein structure and the evolution of protein sequences, using the power of machine learning to integrate these two disparate but equally important ways of capturing biological structure-function relationships. A key objective of this work is to leverage models that, having trained on bio-diverse sequences and structures, can be used to design new therapies. Lastly, Bonneau will discuss recent machine learning-powered drug discovery work that aims to dramatically improve the effectiveness, safety, and cost of new therapies.