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Andrew R. Marks, M.D. is chair and professor of physiology and cellular biophysics at Columbia University. He discovered that ‘leaky’ intracellular calcium-release channels (ryanodine receptors, or RyR) contribute to heart failure, cardiac arrhythmias, impaired exercise capacity, post-traumatic stress disorder and Alzheimer’s disease. He developed a new class of small molecules (Rycals) targeting leaky RyR. Rycals are in clinical trials for heart failure, cardiac arrhythmias, and Duchenne muscular dystrophy.
Investigator, Simons Collaboration on the Global Brain
Assistant Professor of Social and Decision Sciences
Co-Director, Simons Observatory
Andrew Marks
