Vikram K. Mulligan, Ph.D.

Research Scientist, Biomolecular Design, CCB, Flatiron Institute

Vikram Mulligan completed his Ph.D. in the Department of Biochemistry at the University of Toronto, working in the lab of Avi Chakrabartty on molecular mechanisms of protein misfolding in late-onset neurodegenerative diseases. As a postdoc at the University of Washington, he worked to generalize the Rosetta software suite to permit design of mixed-chirality peptide macrocycles, and created the first de novo designed mixed-chirality macrocycles able to bind to a target of therapeutic interest (the New Delhi metallo-β-lactamase 1, an antibiotic resistance factor). Mulligan’s ongoing research interests include harnessing quantum computers to solve the most poorly-scaling problems in protein and heteropolymer modeling, developing methods for rationally designing molecular motions, and incorporating quantum mechanical calculations into classical design pipelines. With Douglas Renfrew, Mulligan co-heads the Biomolecular Design Group.

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