Randy L. Buckner, Ph.D. Harvard Medical School
We will develop a centralized database to integrate data produced by the various Simons Collaboration on Plasticity and the Aging Brain projects. This type of database is essential because different species and individuals within a species follow different trajectories of brain aging, and researchers need a reference framework to link them. The framework we develop will include surface features of aging, such as life span, behavior, and gross morphological and functional changes, as well as deep features, such as shifts in cell states, emergence and attenuation of signaling pathways, and accumulation of underlying genetic and cellular damage. The overarching goal is to develop a database and interfaces that align knowledge about brain aging across model systems and humans.