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A portrait photo of Natalie Sauerwald.
A portrait photo of Natalie Sauerwald.

Research Staff

Natalie Sauerwald, Ph.D.

Associate Research Scientist, Center for Computational Biology

Bio

Natalie Sauerwald joined the Genomics group at the Flatiron Institute in October 2020 to develop new methods for studying human diseases. She received her Ph.D. in Computational Biology from Carnegie Mellon University, focusing on algorithm development in the field of three-dimensional genome structure. Prior to becoming a computational biologist, Natalie studied Mathematics, receiving an M.Sc. from the École Polytechnique Fédérale de Lausanne.

Publications

Variant-resolved prediction of context-specific isoform variation with a graph-based attention model

Cell Genomics, 2026

A. Litman, Zhicheng Pan, Ksenia Sokolova, Joyce Fang, Tess Marvin, N. Sauerwald, et al.

HumanBase: an interactive AI platform for human biology

Nature Methods, January 14, 2026

R. Sealfon, Chandra L. Theesfeld, Julien Funk, N. Sauerwald, and Aaron Wong & Olga Troyanskaya

Decomposition of phenotypic heterogeneity in autism reveals underlying genetic programs.

Nature Genetics, July 2025

A. Litman, N. Sauerwald, L. Green Snyder, J. Foss-Feig, Christopher Y Park, Yun Hao, et al.

CXCR4+ mammary gland macrophageal niche promotes tumor initiating cell activity and immune suppression during tumorigenesis

Nature Communications, May 25, 2025

Eunmi Lee, Jason J. Hong, and N. Sauerwald

Featuring Natalie Sauerwald

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How Mathematical Modeling Identified Subclasses of Autism

Purkinje nerve cells in the cerebellum.

SFARI Hosts 2026 Investigator Meeting

An illustration of a group of hands trying to untangle a large ball of multicolored string.

New Study Reveals Subclasses of Autism by Linking Traits to Genetics

Colorful illustration of a blue RNA strand with highlighted pink and yellow sections, surrounded by clusters of tangled, ribbon-like protein structures against a deep blue background.

New Testing Approach Diagnoses COVID-19 With Near-Perfect Accuracy

Events

CCB Brown Bag Seminar

Seminar

December 7, 2021

1:15–2:30 p.m. ET

Speakers

Natalie Sauerwald, Adam Lamson

A portrait photo of Natalie Sauerwald.
Portrait photo of Adam Lamson

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CCB researchers are pioneering an approach that integrates theory, computation and experimentation—pushing the boundaries of biological inquiry.

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