An immensely complex molecular network of interactions forms the foundation of human biology and disease. Genomic approaches provide a particularly illuminating window to biological systems, and when combined with advanced analysis allow us to learn and model this complexity.

The goal of CCB Genomics research is to interpret and distill this complexity through accurate analysis and modeling of molecular pathways, particularly those in which malfunctions lead to the manifestation of disease. We are inventing integrative methods for systems-level pathway modeling through integrative analysis of genome-scale datasets.

Research Highlights

mRNA-1273 efficacy in a severe COVID-19 model: attenuated activation of pulmonary immune cells after challenge

M. Meyer, Y. Wang, D. Edwards, G. Smith, A. Rubenstein, P. Ramanathan, C. Mire, C. Pietzch, X. Chen, Y. Ge, W. Cheng, C. Henry, A. Woods, L. Ma, G. Stewart-Jones, K. Bock, M. Minai, B. Nagata, S. Periasamy, P. Shi, B. Graham, I. Moore, I. Ramos, O. Troyanskaya, E. Zaslavsky, A. Carfi, S. Sealfon, A. Bukreyev

The mRNA-1273 vaccine was recently determined to be effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from interim Phase…

bioRxiv 2021.01.25.428136

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