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Research Staff

Xi Chen, Ph.D.

Research Scientist, Center for Computational Biology

Bio

Xi Chen joined the Simons Center for Data Analysis in 2016 in the Genomics group. Chen’s research focuses on developing algorithms for processing and statistical analysis of heterogeneous genomics data. He has a Ph.D. in electrical engineering from Virginia Polytechnic Institute and State University, where he worked on developing Bayesian models of transcriptional networks using transcriptomics and genomics data collected from breast cancer cell lines or from patients. Chen holds a B.S. and an M.S. in electrical engineering from Harbin Institute of Technology in China.

Publications

Single-cell epigenetic landscape microenvironment interactions and gene regulatory modules of non-functioning pituitary adenomas

Cell Systems, 2026

Zidong Zhang, Wan Sze Cheng, Keiko Taniguchi-Ponciano, Daniel Marrero-Rodríguez, Gregory R. Smith, Hanna Pincas, et al.

Recurrent immunogenic neoantigens and their cognate T-cell receptors in treatment-resistant metastatic prostate cancer

Cancer Discovery, February 6, 2026

Nofar Gumpert, Shira Sagie, Claudia Arnedo-Pac, Tomer Babu, Chen Weller, Abel Gonzalez-Perez, et al.

Shared multicellular injury programs of acute and chronic kidney disease enable mechanistic patient stratification

January 1, 2026

Robin Fallegger, Sergio A. Gomez-Ochoa, Charlotte Boys, Ricardo Omar Ramirez Flores, Jovan Tanevski, Evanthia Pashos, et al.

Featuring Xi Chen

A Machine-Learning Framework for Prioritizing Disease-Associated Enhancers

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Center for Computational Biology

CCB researchers are pioneering an approach that integrates theory, computation and experimentation—pushing the boundaries of biological inquiry.

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