Phenotyping Sleep

  • Speaker
  • Emmanuel Mignot, M.D., Ph.D.Craig Reynolds Professor of Sleep Medicine, Professor of Psychiatry and Behavioral Sciences, Stanford University
Date & Time

About Simons Foundation Lectures

Simons Foundation Lectures are free public colloquia related to basic science and mathematics. These high-level talks are intended for professors, students, postdocs and business professionals, but interested people from the metropolitan area are welcome as well.
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Sleep as a phenotype has advantages as a research subject over other central nervous system behaviors. Sleep is objectively quantifiable in humans and animals. Sleep is clinically significant to many neuropsychiatric conditions (including autism) and general health issues, with causality starting to be evidenced by genetics. Additionally, sleep research and medicine are uniquely positioned to benefit from ongoing technological revolutions such as hardware miniaturization, large-scale genetic and proteomics, animal models, deep learning and other statistical interpretations.

In this lecture, Emmanuel Mignot will first present the basis of sleep biology as well as the most frequent sleep disorders and their impact. He will explain how these disorders and sleep characteristics are currently monitored in sleep laboratories and how they are interpreted. He will provide an example showing how supervised deep learning of electroencephalogram (EEG) signals can be used to imitate human scoring of sleep stages or events with more reliability and to discover new phenotypes and new applications. From there, he will present a link to what is known on the genetics of sleep and sleep disorders, explaining the current gap — the fact current studies have only used subjective reports of sleep and sleep symptoms. The need for large scale objective sleep recording studies with genomic and proteomic analysis will be emphasized. Such studies and analyses would allow for the understanding of molecular pathways regulating sleep and circadian biology. He will point out that proteomics allows for the creation of multivariate models that can correlate with complex physiological phenomena such as organ function, aging, sleep debt or circadian phase. To ensure complete convergence of these technologies, a need exists for designing a complete, easy-to-wear, at-home sleep disorder hardware evaluation system. Such hardware is feasible and could happen soon with existing technology.

Further instructions and access to join the webinar will be sent to all registrants upon sign up.


About the Speaker

Mignot is the Craig Reynolds Professor of Sleep Medicine at Stanford University. He discovered that human narcolepsy is caused by an autoimmune loss of approximately 20,000 hypothalamic neurons secreting the wake-promoting peptide hypocretin (also known as orexin). He also identified HLA-DQB1*06:02 and T-cell receptor genes as major susceptibility genes, which act together to promote a selective autoimmune process triggered by influenza A. Mignot has received numerous awards and is a member of the National Academy of Sciences and the National Academy of Medicine.

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