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Transcriptional and Epigenetic Mechanisms of Depression

Depression is a common, chronic, and debilitating disease. Although many patients benefit from antidepressant medications or other therapies, only about half show complete remission. Factors that precipitate depression, such as stress, are incompletely understood. We have used chronic social defeat stress as an animal model of depression. Prolonged exposure to an aggressor induces lasting changes in behavior such as social avoidance and anhedonia-like symptoms, which are reversed by chronic (but not acute) treatment with available antidepressants.

April 11, 2014: Conference on Theory & Biology

This day-long conference will highlight areas where theoretical ideas are having an impact on the life sciences, and will be of interest to established researchers, postdoctoral fellows and graduate students working in the life sciences and allied fields.

April 15, 2014: Von Neumann Machines and Molecular Darwinism

In this lecture, Gerald Joyce focuses on the perpetuation of genetic information as a defining characteristic of life. He draws a connection between digital computers (von Neumann machines), especially those with the capacity to self-reproduce, and molecular Darwinian systems that maintain heritable ‘bits’ of information, which are refined through evolution.

April 15, 2014: Von Neumann Machines and Molecular Darwinism

In this lecture, Gerald Joyce focuses on the perpetuation of genetic information as a defining characteristic of life. He draws a connection between digital computers (von Neumann machines), especially those with the capacity to self-reproduce, and molecular Darwinian systems that maintain heritable ‘bits’ of information, which are refined through evolution.

Von Neumann Machines and Molecular Darwinism

Gerald D. Fischbach Auditorium 160 5th Avenue, New York, NY, United States

In this lecture, Gerald Joyce focuses on the perpetuation of genetic information as a defining characteristic of life. He draws a connection between digital computers (von Neumann machines), especially those with the capacity to self-reproduce, and molecular Darwinian systems that maintain heritable ‘bits’ of information, which are refined through evolution.

April 23, 2014: New Insights and Approaches for Studying Rett Syndrome, an Autism-Associated Disorder

A central goal in neuroscience is determining the genetic basis of neurological disorders — from autism to brain tumors. Many of these pathological states result from defects in gene regulatory programs that are fundamental to all cell types but lead to dysfunction specifically within the nervous system. Gail Mandel investigates the basis of this phenomenon and has identified cell-cell interactions between neurons and glia involved in pathological states of brain development. Mandel has ameliorated the neuropathology of one autism spectrum disorder, Rett syndrome, by genetically replacing the defective MeCP2 gene with a good copy of the gene in astrocytes – glia cells in the brain. She is now exploring the underlying mechanisms crucial for neuronal signaling.

New Insights and Approaches for Studying Rett Syndrome, an Autism-Associated Disorder

Gerald D. Fischbach Auditorium 160 5th Avenue, New York, NY, United States

A central goal in neuroscience is determining the genetic basis of neurological disorders — from autism to brain tumors. Many of these pathological states result from defects in gene regulatory programs that are fundamental to all cell types but lead to dysfunction specifically within the nervous system. Gail Mandel investigates the basis of this phenomenon and has identified cell-cell interactions between neurons and glia involved in pathological states of brain development. Mandel has ameliorated the neuropathology of one autism spectrum disorder, Rett syndrome, by genetically replacing the defective MeCP2 gene with a good copy of the gene in astrocytes – glia cells in the brain. She is now exploring the underlying mechanisms crucial for neuronal signaling.

April 30, 2014: Where is Fundamental Physics Heading?

In recent decades, physicists and astronomers have discovered two beautiful standard models, one for the quantum world of extremely short distances and one for the universe as a whole. Both models have had spectacular success, but there are also strong arguments for new physics beyond these models.

Where is Fundamental Physics Heading?

Gerald D. Fischbach Auditorium 160 5th Avenue, New York, NY, United States

In recent decades, physicists and astronomers have discovered two beautiful standard models, one for the quantum world of extremely short distances and one for the universe as a whole. Both models have had spectacular success, but there are also strong arguments for new physics beyond these models.

Big Data Analytics and a Path to Enhancing Our Understanding of Human Disease

Dr. Schadt provides an overview of how his team organizes very large scale data across many different types, and then integrates these data using sophisticated mathematical algorithms to construct predictive network models of disease, and discusses the application of this type of modeling in the cancer arena.

May 21, 2014: Probabilistic Topic Models of Text and Users

Probabilistic topic models provide a suite of tools for analyzing large collections of electronic documents. A traditional topic model analyzes a collection of documents to discover its hidden themes.  These themes can be used to organize, visualize, summarize and navigate the collection. Many collections are associated with corresponding reader behavior data, which is useful both for making predictions about readers (such as which articles they will like) and in understanding patterns in how they read.

 

Probabilistic Topic Models of Text and Users

Gerald D. Fischbach Auditorium 160 5th Avenue, New York, NY, United States

Probabilistic topic models provide a suite of tools for analyzing large collections of electronic documents. A traditional topic model analyzes a collection of documents to discover its hidden themes.  These themes can be used to organize, visualize, summarize and navigate the collection. Many collections are associated with corresponding reader behavior data, which is useful both for making predictions about readers (such as which articles they will like) and in understanding patterns in how they read.

May 28, 2014: Keeping Your Brain in Balance: Do Defects in Neuronal Homeostasis Contribute to Autism Spectrum Disorders?

Although most people regularly tune up their cars, you probably haven’t needed to bring your brain in for a tune-up, despite the fact that the human brain is far more complex than the internal combustion engine. What’s more, unlike most machines, your brain is constantly changing in order to store memories and adapt to a fluid environment. Our brains are faced with a fundamental challenge: They must preserve the integrity of the neural circuits that subserve behaviors over the lifetime of an organism, while at the same time allowing plastic mechanisms to shape and fine-tune their function.

Keeping Your Brain in Balance: Do Defects in Neuronal Homeostasis Contribute to Autism Spectrum Disorders?

Gerald D. Fischbach Auditorium 160 5th Avenue, New York, NY, United States

Although most people regularly tune up their cars, you probably haven’t needed to bring your brain in for a tune-up, despite the fact that the human brain is far more complex than the internal combustion engine. What’s more, unlike most machines, your brain is constantly changing in order to store memories and adapt to a fluid environment. Our brains are faced with a fundamental challenge: They must preserve the integrity of the neural circuits that subserve behaviors over the lifetime of an organism, while at the same time allowing plastic mechanisms to shape and fine-tune their function.

Symposium on Evidence in the Natural Sciences

FRIDAY, MAY 30, 2014 Scientific Program: 8:00 AM - 3:15 PM Evening Program: 4:30 - 7:45 PM Gerald D. Fischbach Auditorium 160 5th Avenue, New York, New York, 10010 What is the difference between evidence, fact, and proof? Can we quantify evidence; is something more evident than something else? What does it take to convince...

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