Sequence-structure-function relationships in the microbial protein universe
For the past half-century, structural biologists relied on the notion that similar protein sequences give rise to similar structures and…
bioRxivSystems Biology
At the Systems Biology group, we are developing new methods to learn the networks that run life’s program.
Key aims include developing new methods to annotate genes (characterize the parts list for biology) and building new methods that learn biological networks, and eventually dynamic models (put the parts together). These network models will help us to predict the functional effect of genetic variation, design interventions and therapies, and understand how living systems respond to changes in their environment.
Research Highlights
Multi-omic analysis along the gut-brain axis points to a functional architecture of autism
J. Morton, Dong-Min Jin, R. Bonneau
Autism is a highly heritable neurodevelopmental disorder characterized by heterogeneous cognitive, behavioral and communication impairments. Disruption of the gut-brain axis…
bioRxivSARS-CoV-2 RNA concentrations in wastewater foreshadow dynamics and clinical presentation of new COVID-19 cases
Fuqing Wu, Amy Xiao, R. Bonneau, et al.
Current estimates of COVID-19 prevalence are largely based on symptomatic, clinically diagnosed cases. The existence of a large number of…
Science of The Total EnvironmentUpcoming Events
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12 Wed -
Meeting 4:00 - 5:00 p.m.
Systems Biology Group Meeting
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Meeting 4:00 - 5:00 p.m.
