Key aims include developing new methods to annotate genes (characterize the parts list for biology) and building new methods that learn biological networks, and eventually dynamic models (put the parts together). These network models will help us to predict the functional effect of genetic variation, design interventions and therapies, and understand how living systems respond to changes in their environment.
We use computational design coupled with experimental characterization to systematically investigate the design principles for macrocycle membrane permeability and oral…
CellThe previously reported Q is a thermoresponsive coiled-coil protein capable of higher-order supramolecular assembly into fibers and hydrogels with upper…
Molecular Systems Design and EngineeringFor the past half-century, structural biologists relied on the notion that similar protein sequences give rise to similar structures and…
bioRxiv
