Biophysics & Development Seminar: Anna Kreshuk, EMBL

Title: Single cells in a whole organism: image analysis to prepare the ground

Abstract: Cutting-edge volume electron microscopy allows to image very large samples, up to the whole animal level for small organisms. I will talk about the methods we developed to segment all cells and all cell nuclei in a volume like this, encompassing a whole 6-day old marine worm platynereis dumerilii. I will also show how the segmented cells can be assigned to a gene expression profile through correlation with light microscopy volumes and how morphological properties of cells can be used to enrich downstream analysis.