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Genomics in Single Cells and Microbiomes

Gerald D. Fischbach Auditorium 160 5th Avenue, New York, NY, United States

Speakers: Curtis Huttenhower, Aviv Regev, Dana Pe’er, Michael Schatz Curtis Huttenhower High-precision Functional Profiling of Microbial Communities and the Human Microbiome https://vimeo.com/125281142 Aviv Regev Towards a Human Cell Atlas https://vimeo.com/125270869 Dan Pe'er Single Cell Mapping of Developmental Trajectories Underlying Health and Disease https://vimeo.com/125270868 Michael Schatz Algorithms for Single Cell and Single Molecule Biology https://vimeo.com/125281143

Reproducible Research and the Common Task Method

Gerald D. Fischbach Auditorium 160 5th Avenue, New York, NY, United States

In this lecture, Mark Liberman will describe the origins and development of the ‘Common Task’ method in DARPA’s human language technology program, its broader influence on recent research and development practices, and its lessons for the future.

Imaging as Exploration

Gerald D. Fischbach Auditorium 160 5th Avenue, New York, NY, United States

Advanced data generation capabilities require other enhanced abilities — with increasing data size and complexity, the development of more efficient acquisition and analysis methods is essential. In this lecture, Lawrence R. Frank will discuss how this new paradigm of imaging exploration is manifest.

Illuminating Biology at the Nanoscale with Super-Resolution Florescence Microscopy

Stochastic optical reconstruction microscopy (STORM), breaks the diffraction limit on light microscopy by using selective activation of photo-switchable fluorescent probes to temporally separate the spatially overlapping images of individual molecules. This approach has allowed multicolor and 3-D imaging of living cells with nanometer-scale resolution, enabling discoveries of novel sub-cellular structures. In this talk, Prof. Zhuang will discuss her group's development of STORM and its biological applications.

Extra-Solar Planets: Search, Characterization and Population Inferences

Gerald D. Fischbach Auditorium 160 5th Avenue, New York, NY, United States

David W. Hogg will explore how planets are discovered in the Kepler dataset, how the data are understood and how researchers can make inferences about the full population of planets in the galaxy.

Solving the 3-D Puzzle of Rotation Assignment in Single Particle Cryo-Electron Microscopy

Gerald D. Fischbach Auditorium 160 5th Avenue, New York, NY, United States

This lecture will explore algorithms for estimating the unknown pose parameters. The main focus will be on algorithms that are based on semidefinite programming relaxations that can be viewed as extensions to existing approximation algorithms to max-cut and unique games, two fundamental problems in theoretical computer science.

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