The Center for Computational Biology develops new and innovative methods of examining data in the biological sciences whose scale and complexity have historically resisted analysis.
Featured News
Center for Computational Biology
A Tug-of-War Explains a Decades-Old Question About How Bacteria Swim
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Bacteria tails rotate counterclockwise to propel the bacteria through liquid environments and clockwise to change direction. Previous research has suggested that the direction of the spin depends on a domino effect experienced by a ring of proteins in the bacterium’s tail. However, new research from Flatiron Institute scientists proposes that an energy-consuming, mechanical tug-of-war among these proteins is the deciding factor.
CCB’s mission is to develop modeling tools and theory for understanding biological processes and to create computational frameworks that will enable the analysis of the large, complex data sets being generated by new experimental technologies.
Research Areas
Collaborative Work
Structural and Molecular Biophysics
Underlying all biological processes are molecules and their interactions with each other. However, our ability to understand how these molecules function over biologically relevant scales remains very limited.
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CCBx
The Center for Computational Biologyx (CCBx) is an effort by the Center for Computational Biology (CCB) to (a) create and validate quantitative techniques and (b) develop and test theories of biological systems that are predictive of these systems’ behaviors and responses to genetic, chemical and physical perturbations.
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Upcoming Events
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16 Mon -
Meeting 10:30 a.m. - 12:00 p.m.
Developmental Dynamics Group Meeting
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Meeting 10:30 a.m. - 12:00 p.m.
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17 Tue -
Meeting 10:00 - 11:00 a.m.
Biophysical Modeling Group Meeting
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Meeting 10:00 - 11:00 a.m.
Biophysical Modeling Group Meeting
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Meeting 2:00 - 3:00 p.m.
COMPASS Meeting
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Meeting 10:00 - 11:00 a.m.
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18 Wed -
Meeting 12:00 - 1:00 p.m.
Computer Vision & Machine Learning Meeting
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Meeting 1:30 - 3:30 p.m.
Genomics Group Meeting
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Meeting 12:00 - 1:00 p.m.
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23 Mon -
Meeting 10:30 a.m. - 12:00 p.m.
Developmental Dynamics Group Meeting
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Meeting 10:30 a.m. - 12:00 p.m.
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24 Tue -
Meeting 10:00 - 11:00 a.m.
Biophysical Modeling Group Meeting
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Meeting 12:00 - 2:00 p.m.
Genomics Group Meeting
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Meeting 2:00 - 3:00 p.m.
COMPASS Meeting
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Meeting 10:00 - 11:00 a.m.
Publication Highlights
Exploring How Workflow Variations in Denaturation-Based Assays Impact Global Protein–Protein Interaction Predictions
Tavis J. Reed, Laura M. Haubold, O. Troyanskaya, et al.
Protein denaturation-based assays, such as thermal proximity coaggregation (TPCA) and ion-based proteome-integrated solubility alteration (I-PISA), are powerful tools for characterizing…
Molecular & Cell ProteomicsComparing cryo-EM methods and molecular dynamics simulation to investigate heterogeneity in ligand-bound TRPV1
Cryogenic electron microscopy (cryo-EM) has emerged as a powerful method for resolving the structure of biological macromolecules. Recently, several computational…
Nature CommunicationsAge-related nigral downregulation of the Parkinson’s risk factor FAM49B primes human microglia for inflammaging
Jacqueline Martin, C. Park, O. Troyanskaya, et al.
Parkinson’s Disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc), which is…
npj AgingDirector
Software
aLENS
This is the simulation tool for tracking assemblies of microtubules driven by motor proteins.
STKFMM
This is a numerical computation package for various single- and double-layer kernels for Laplace and Stokes operators in boundary integral methods, implemented on top of the highly-optimized kernel independent fast-multipole method package PVFMM.
humanbase
Data-driven predictions of gene expression, function, regulation, and interactions in human.
DeepSEA
Deep learning-based algorithmic framework for predicting chromatin effects
FNTM
Functional Networks of Tissues in Mouse
GIANT
Genome-wide Scale functional interaction networks for 144 human tissues and cell types
IMP 2.0
Integrative Multi-species Prediction
KNNimpute
K-Nearest Neighbors Imputation
Nano-Dissection
This server performs in silico nano-dissection, an approach we developed to identify genes with novel cell-lineage specific expression.
SEEK
Search-Based Exploration of Expression Compendium [Human]
SkellySim
SkellySim is a simulation package for simulating cellular components such as flexible filaments, motor proteins, and arbitrary rigid bodies.
Sleipnir
Sleipnir Library for Computational Functional Genomics
URSA(HD)
A data-driven perspective to your gene expression profile for human tissues and diseases.
Masala
The public repository for the Core library of the Masala software suite. Masala is a set of free and open-source tools for biomolecular modelling, with a plugin-based infrastructure that makes it easy to extend other software.