Publications

Genetically encoded voltage indicators (GEVIs) enable monitoring of neuronal activity at high spatial and temporal resolution. However, the utility of existing GEVIs has been limited by the brightness and photostability of fluorescent proteins and rhodopsins. We engineered a GEVI, called Voltron, that uses bright and photostable synthetic dyes instead of protein-based fluorophores, thereby extending the number of neurons imaged simultaneously in vivo by a factor of 10 and enabling imaging for significantly longer durations relative to existing GEVIs. We used Voltron for in vivo voltage imaging in mice, zebrafish, and fruit flies. In the mouse cortex, Voltron allowed single-trial recording of spikes and subthreshold voltage signals from dozens of neurons simultaneously over a 15-minute period of continuous imaging. In larval zebrafish, Voltron enabled the precise correlation of spike timing with behavior

We provide an overview of the science case, instrument configuration and project plan for the next-generation ground-based cosmic microwave background experiment CMB-S4, for consideration by the 2020 Decadal Survey.

Departures of the energy spectrum of the cosmic microwave background (CMB) from a perfect blackbody probe a fundamental property of the universe -- its thermal history. Current upper limits, dating back some 25 years, limit such spectral distortions to 50 parts per million and provide a foundation for the Hot Big Bang model of the early universe. Modern upgrades to the 1980's-era technology behind these limits enable three orders of magnitude or greater improvement in sensitivity. The standard cosmological model provides compelling targets at this sensitivity, spanning cosmic history from the decay of primordial density perturbations to the role of baryonic feedback in structure formation. Fully utilizing this sensitivity requires concurrent improvements in our understanding of competing astrophysical foregrounds. We outline a program using proven technologies capable of detecting the minimal predicted distortions even for worst-case foreground scenarios.

Moiré engineering has recently emerged as a capable approach to control quantum phenomena in condensed matter systems. In van der Waals heterostructures, moiré patterns can be formed by lattice misorientation between adjacent atomic layers, creating long range electronic order. To date, moiré engineering has been executed solely in stacked van der Waals multilayers. Herein, we describe our discovery of electronic moiré patterns in films of a prototypical magnetoresistive oxide La0.67Sr0.33MnO3 (LSMO) epitaxially grown on LaAlO3 (LAO) substrates. Using scanning probe nano-imaging, we observe microscopic moiré profiles attributed to the coexistence and interaction of two distinct incommensurate patterns of strain modulation within these films. The net effect is that both electronic conductivity and ferromagnetism of LSMO are modulated by periodic moiré textures extending over mesoscopic scales. Our work provides an entirely new route with potential to achieve spatially patterned electronic textures on demand in strained epitaxial materials.

Upon chemical substitution of oxygen with fluor, LaMnAsO has been electron-doped in experiments, resulting in samples with remarkably high Seebeck coefficients of around −300 μV/K at room temperature and 3% doping. Within the framework of density functional theory plus dynamical mean-field theory (DFT+DMFT) we not only are able to reproduce these experimental observations, but also can provide a thorough investigation of the underlying mechanisms. By considering electronic correlations in the half-filled Mn-3d shells, we trace the high Seebeck coefficient back to an asymmetry in the spectral function, which is due to the emergence of an incoherent spectral weight under doping and a strong renormalization of the unoccupied states. This is only possible in correlated systems and cannot be explained by DFT-based band structure calculations.

We explore the structure of the element abundance--age--orbit distribution of the stars in the Milky Way's low-α disk, by (re-)deriving precise [Fe/H], [X/Fe] and ages, along with orbits, for red clump stars from the APOGEE survey. There has been a long-standing theoretical expectation and observational evidence that metallicity ([Fe/H]) and age are informative about a star's orbit, e.g. about its angular momentum and the corresponding mean Galactocentric distance or its vertical motion. Indeed, our analysis of the APOGEE data confirms that [Fe/H] or age alone can predict the stars' orbits far less well than the combination of the two. Remarkably, we find and show explicitly, that for known [Fe/H] and age, the other abundances [X/Fe] of Galactic disk stars can be predicted well (on average to 0.02 dex) across a wide range of Galactocentric radii, and therefore provide little additional information, e.g. for predicting their orbit. While the age-abundance space for metal poor stars and potentially for stars near the Galactic center is rich or complex, for the bulk of the Galaxy's low-α disk it is simple: [Fe/H] and age contain most information, unless [X/Fe] can be measured to 0.02, or better. Consequently, we do not have the precision with current (and likely near-future) data to assign stars to their individual (coeval) birth clusters, from which the disk is presumably formed. We can, however, place strong constraints on future models of galactic evolution, chemical enrichment and mixing.

We propose a solution to the problem of Bloch electrons in a homogeneous magnetic field by including the quantum fluctuations of the photon field. A generalized quantum electrodynamical (QED)-Bloch theory from first principles is presented. In the limit of vanishing quantum fluctuations, we recover the standard results of solid-state physics: the fractal spectrum of the Hofstadter butterfly. As a further application, we show how the well-known Landau physics is modified by the photon field and that Landau polaritons emerge. This shows that our QED-Bloch theory does not only allow us to capture the physics of solid-state systems in homogeneous magnetic fields but also novel features that appear at the interface of condensed matter physics and quantum optics.

We describe how to incorporate symmetries of the Hamiltonian into auxiliary-field quantum Monte Carlo calculations (AFQMC). Focusing on the case of Abelian symmetries, we show that the computational cost of most steps of an AFQMC calculation is reduced by $N_k^{-1}$, where $N_k$ is the number of irreducible representations of the symmetry group. We apply the formalism to a molecular system as well as to several crystalline solids. In the latter case, the lattice translational group provides increasing savings as the number of k points is increased, which is important in enabling calculations that approach the thermodynamic limit. The extension to non-Abelian symmetries is briefly discussed.