Lowe is the chair of the Cancer Biology and Genetics Program at Memorial Sloan Kettering Cancer Center (MSKCC) and investigator in the Howard Hughes Medical Institute. He received his B.S. from the University of Wisconsin-Madison, and his Ph.D. from the Massachusetts Institute of Technology. Before joining MSKCC, Lowe was a faculty member at Cold Spring Harbor Laboratory in New York. He is a member of the American Academy of Arts and Sciences and the National Academy of Sciences.