From the bioRxiv: A Selection of Recently Posted Papers from SCPAB Investigators and Others

Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.

Age differences in aperiodic neural activity measured with resting EEG

Ashley Merkin, Sabrina Sghirripa, Lynton Graetz, Ashleigh E Smith, Brenton Hordacre, Richard Harris, Julia Pitcher, John Semmler, Nigel C Rogasch and Mitchell Goldsworthy

bioRxiv. posted 1 September 2021

http://biorxiv.org/content/early/2021/09/01/2021.08.31.458328

The Digital Brain Bank, an open access platform for post-mortem datasets

Benjamin C. Tendler, Taylor Hanayik, Olaf Ansorge, Sarah Bangerter-Christensen, Gregory S. Berns, Mads F. Bertelsen, Katherine L. Bryant, Sean Foxley, Martijn van den Heuvel, Amy F.D. Howard, Istvan Huszar, Alexandre A. Khrapitchev, Anna Leonte, Paul R. Manger, Ricarda A.L. Menke, Jeroen Mollink, Duncan Mortimer, Menuka Pallebage-Gamarallage, Lea Roumazeilles, Jerome Sallet, Lianne H. Scholtens, Connor Scott, Adele Smart, Martin R. Turner, Chaoyue Wang, Saad Jbabdi, Rogier B. Mars and Karla L. Miller

bioRxiv. posted 22 June 2021

http://biorxiv.org/content/early/2021/09/01/2021.06.21.449154

Cell types and clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics

Michael Ratz, Leonie von Berlin, Ludvig Larsson, Marcel Martin, Jakub Orzechowski Westholm, Gioele La Manno, Joakim Lundeberg and Jonas Frisen

bioRxiv. posted 1 September 2021

http://biorxiv.org/content/early/2021/09/01/2021.08.31.458418

Weakly activated core inflammation pathways were identified as a central signaling mechanism contributing to the chronic neurodegeneration in Alzheimer’s disease

Fuhai Li, Abdallah Eteleeb, William Buchser, Guoqiao Wang, Chengjie Xiong, Philip R. Payne, Eric McDade, Celeste M. Karch, Oscar Harari and Carlos Cruchaga

bioRxiv. posted 1 September 2021

http://biorxiv.org/content/early/2021/09/01/2021.08.30.458295

Differential regulation of mouse hippocampal gene expression sex differences by chromosomal content and gonadal sex

Sarah R Ocanas, Victor A Ansere, Kyla B Tooley, Niran Hadad, Ana J Chucair-Elliott, David R Stanford, Shannon Rice, Benjamin Wronowski, Jessica M Hoffman, Steven N Austad, Michael B Stout and Willard M Freeman

bioRxiv. posted 2 September 2021

http://biorxiv.org/content/early/2021/09/02/2021.09.01.458115

MOSCATO: A Supervised Approach for Analyzing Multi-Omic Single-Cell Data

Lorin M Towle-Miller and Jeffrey C Miecznikowski

bioRxiv. posted 4 September 2021

http://biorxiv.org/content/early/2021/09/04/2021.09.02.458781

Neural circuit dynamics of drug-context associative learning in the hippocampus

Yanjun Sun and Lisa M Giocomo

bioRxiv. posted 5 September 2021

http://biorxiv.org/content/early/2021/09/05/2021.09.02.458796

Global Mapping of Mouse CSF Flow via HEAP-METRIC Phase-contrast MRI

Juchen Li, Mengchao Pei, Binshi Bo, Xinxin Zhao, Jing Cang, Fang Fang and Zhifeng Liang

bioRxiv. posted 6 September 2021

http://biorxiv.org/content/early/2021/09/06/2021.09.04.459006

Ascertaining cells’ synaptic connections and RNA expression simultaneously with massively barcoded rabies virus libraries

Arpiar Saunders, Kee Wui Huang, Cassandra Vondrak, Christina Hughes, Karina Smolyar, Harsha Sen, Adrienne C Philson, James Nemesh, Alec Wysoker, Seva Kashin, Bernardo L Sabatini and Steven A McCarroll

bioRxiv. posted 6 September 2021

http://biorxiv.org/content/early/2021/09/06/2021.09.06.459177

Real Age Prediction from the Transcriptome with RAPToR

Romain Bulteau and Mirko Francesconi

bioRxiv. posted 8 September 2021

http://biorxiv.org/content/early/2021/09/08/2021.09.07.459270

Microglia drive pockets of neuroinflammation in middle age

Eric N. Moca, Daniela Lecca, Keenan T. Hope, David Tweedie, Shanaya Sidhu, Lindsay Masukawa, Hannah Sitoy, Rose Mathew, Daniel R. Saban, Nigel H. Greig, Lindsay M. De Biase

https://www.biorxiv.org/content/10.1101/2021.02.02.429070v2

Lipid chaperone LBP-8 coordinates with nuclear factors to promote longevity in Caenorhabditis elegans

Jonathon Duffy, Qinghao Zhang, Sung Y Jun and Meng C Wang

bioRxiv. posted 9 September 2021

http://biorxiv.org/content/early/2021/09/09/2021.09.09.459489

Distinct and diverse chromatin-proteomes of ageing mouse organs reveal protein signatures that correlate with physiological functions

Giorgio Oliviero, Sergey Kovalchuk, Adelina Rogowska-Wrzesinska, Veit Schwämmle and Ole N. Jensen

bioRxiv. posted 12 September 2021

http://biorxiv.org/content/early/2021/09/12/2021.09.09.459706

Activation of the CaMKII-Sarm1-ASK1 MAP kinase pathway protects against axon degeneration caused by loss of mitochondria

Chen Ding, Youjun Wu, Hadas Dabas and Marc Hammarlund

bioRxiv. posted 12 September 2021

http://biorxiv.org/content/early/2021/09/12/2021.09.12.459970

Reduced plasticity in coupling strength in the SCN clock in aging as revealed by Kuramoto modelling

Anouk Willemijn van Beurden, Janusz Meylahn, Stefan Achterhof, Johanna Meijer and Jos Rohling

bioRxiv. posted 14 September 2021

http://biorxiv.org/content/early/2021/09/14/2021.09.13.460004

Proximal CA3 is the primary locus of age-related pattern separation deficits in rats

Heekyung Lee, Arjuna Tilekeratne, Nick Lukish, Zitong Wang, Scott Zeger, Michela Gallagher and James J Knierim

bioRxiv. posted 16 September 2021

http://biorxiv.org/content/early/2021/09/16/2021.09.14.460329

Longitudinal effects of using and discontinuing CNS medications on cognitive functioning

Elise Koch, Kristina Johnell and Karolina Kauppi

bioRxiv. posted 16 September 2021

http://biorxiv.org/content/early/2021/09/16/2021.09.13.460082

Lifelong musical activity is associated with multi-domain cognitive and brain benefits in older adults

Adriana Boettcher, Alexis Zarucha, Theresa Koebe, Malo Gaubert, Angela Hoeppner, Klaus Fabel, Slawek Altenstein, Claudia Bartels, Katharina Buerger, Peter Dechent, Laura Dobisch, Michael Ewers, Klaus Fliessbach, Silka Dawn Freiesleben, Ingo Frommann, John-Dylan Haynes, Daniel Janowitz, Ingo Kilimann, Luca Kleineidam, Christoph Laske, Franziska Maier, Coraline Metzger, Matthias Munk, Robert Perneczky, Oliver Peters, Josef Priller, Boris-Stephan Rauchmann, Nina Roy, Klaus Scheffler, Anja Schneider, Annika Spottke, Stefan J. Teipel, Steffen Wolfsgruber, Jens Wiltfang, Renat Yakupov, Emrah Duzel, Frank Jessen, Sandra Roeske, Michael Wagner, Gerd Kempermann, Miranka Wirth and DELCODE study group

bioRxiv. posted 17 September 2021

http://biorxiv.org/content/early/2021/09/17/2021.09.15.460202

Adiponectin receptor agonist AdipoRon improves skeletal muscle function in aged mice

Priya Balasubramanian, Anne E Schaar, Grace E Gustafson, Alex B Smith, Porsha R Howell, Angela Greenman, Scott Baum, Ricki J Colman, Dudley W Lamming, Gary M Diffee and Rozalyn Anderson

bioRxiv. posted 17 September 2021

http://biorxiv.org/content/early/2021/09/17/2021.09.16.460597

High-order functional interactions in ageing explained via alterations in the connectome in a whole-brain model

Marilyn Gatica, Fernando E. Rosas, Pedro A.M. Mediano, Ibai Diez, Stephan P. Swinnen, Patricio Orio, Rodrigo Cofre and Jesus M. Cortes

bioRxiv. posted 17 September 2021

http://biorxiv.org/content/early/2021/09/17/2021.09.15.460435

Regulation of the cognitive aging process by the transcriptional repressor RP58

Tomoko Tanaka, Shinobu Hirai, Hiroyuki Manabe, Kentaro Endo, Hiroko Shimbo and haruo okado

bioRxiv. posted 20 September 2021

http://biorxiv.org/content/early/2021/09/20/2021.09.18.460879

Characterizing the human methylome across the life course: findings from eight UK-based studies

Esther Walton, Riccardo Marioni, Hannah R Elliott, Simon R Cox, Ian R Deary, Alun D Hughes, Therese Tillin, Meena Kumari, Tom Woofenden, Juan E Castillo-Fernandez, Jordana Tzenova Bell, Alissa Goodman, George Ploubidis, Kate Tilling, Matthew Suderman, Tom R Gaunt, Erin C Dunn, Andrew Smith and Caroline Relton

bioRxiv. posted 20 September 2021

http://biorxiv.org/content/early/2021/09/20/2021.09.18.460916

The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia

Ralda Nehme, Olli Pietilainen, Mykyta Artomov, Matthew Tegtmeyer, Christina Bell, Andrea Ganna, Tarjinder Singh, Aditi Trehan, Vera Valakh, John Sherwood, Danielle Manning, Emily Peirent, Rhea Malik, Ellen J. Guss, Derek Hawes, Amanda Beccard, Anne M. Bara, Dane Z. Hazelbaker, Emanuela Zuccaro, Giulio Genovese, Alexander A. Loboda, Anna Neumann, Christina Lilliehook, Outi Kuismin, Eija Hamalainen, Mitja Kurki, Christina M. Hultman, Anna K. Kahler, Joao A. Paulo, Jon Madison, Bruce Cohen, Donna McPhie, Rolf Adolfsson, Roy Perlis, Ricardo Dolmetsch, Samouil Farhi, Steven McCarroll, Steven Hyman, Ben Neale, Lindy E. Barrett, Wade Harper, Aarno Palotie, Mark Daly and Kevin Eggan

bioRxiv. posted 22 September 2021

http://biorxiv.org/content/early/2021/09/22/2021.09.22.461360

White matter hyperintensities may be an early marker for age-related cognitive decline in the ADNI cohort

Cassandra Morrison, Mahsa Dadar, Sylvia Villeneuve and D. Louis Collins

bioRxiv. posted 24 September 2021

http://biorxiv.org/content/early/2021/09/24/2021.09.23.461560

A network model of glymphatic flow under different experimentally-motivated parametric scenarios

Jeffrey Tithof, Kimberly A. S. Boster, Peter A. R. Bork, Maiken Nedergaard, John H. Thomas and Douglas H. Kelley

bioRxiv. posted 24 September 2021

http://biorxiv.org/content/early/2021/09/24/2021.09.23.461519

Aging reduces calreticulin expression and alters spontaneous calcium signals in astrocytic endfeet of the mouse dorsolateral striatum

Sara M. Zarate, Taylor E. Huntington, Pooneh Bagher, and Rahul Srinivasan

bioRxiv posted 25 September 2021

https://www.biorxiv.org/content/10.1101/2021.09.24.461710

Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making

Simon Musall, Xiaonan Richard Sun, Hemanth Mohan, Xu An, Steven Gluf and Anne K. Churchland

bioRxiv. posted 27 September 2021

http://biorxiv.org/content/early/2021/09/27/2021.09.27.461599