Center for Computational Biology

Simons Foundation

The Center for Computational Biology develops new and innovative methods of examining data in the biological sciences whose scale and complexity have historically resisted analysis.

CCB’s mission is to develop modeling tools and theory for understanding biological processes and to create computational frameworks that will enable the analysis of the large, complex data sets being generated by new experimental technologies.

Groups

Biophysical Modeling The Biophysical Modeling group focuses on the modeling and simulation of complex systems that arise in biology and soft condensed matter physics. Read More

Genomics An immensely complex molecular network of interactions forms the foundation of human biology and disease. Genomic approaches provide a particularly illuminating window to biological systems, and when combined with advanced analysis allow us to learn and model this complexity. Read More

Neuroscience Our goal is to understand how the brain analyzes large and complex datasets streamed by sensory organs in order to aid efforts at building artificial neural systems and treating mental illness. Read More

Systems Biology At the Systems Biology group, we are developing new methods to learn the networks that run life’s program. Read More

News & Announcements

Deep Beneath Your Feet, They Live in the Octillions (New York Times)

The Author File: Olga Troyanskaya (Nature Methods)

DNA ‘Dances’ in First Explanation of How Genetic Material Flows Through a Nucleus By Thomas Sumner

Research Highlights

2019

Computing collision stress in assemblies of active spherocylinders: applications of a fast and generic geometric method

W. Yan, Huan Zhang, M. Shelley

The Journal of Chemical Physics

February 1, 2019

From cytoskeletal assemblies to living materials

P. Foster, S. Fürthauer, M. Shelley, D. Needleman

Many subcellular structures contain large numbers of cytoskeletal filaments. Such assemblies underlie much of cell division, motility, signaling, metabolism, and…

Current Opinion in Cell Biology

January 31, 2019

Coarse-graining the dynamics of immersed and driven fiber assemblies

D. Stein, M. Shelley

An important class of fluid-structure problems involve the dynamics of ordered arrays of immersed, flexible fibers. While specialized numerical methods…

arXiv:1902.00049

Director

Leslie Greengard, M.D., Ph.D.

Director, CCM; Interim Director, CCB

Leslie Greengard joined the Simons Foundation in 2013 as founding director of the Simons Center for Data Analysis, now called the Center for Computational Biology. Prior to that, Greengard served as director of the Courant Institute of Mathematical Sciences at New York University.

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