Center for Computational Biology

Simons Foundation

The Center for Computational Biology develops new and innovative methods of examining data in the biological sciences whose scale and complexity have historically resisted analysis.

CCB’s mission is to develop modeling tools and theory for understanding biological processes and to create computational frameworks that will enable the analysis of the large, complex data sets being generated by new experimental technologies.

Groups

Biophysical Modeling The Biophysical Modeling group focuses on the modeling and simulation of complex systems that arise in biology and soft condensed matter physics. Read More

Developmental Dynamics The Developmental Dynamics group combines experiments, theory and computing to elucidate the contributions of encoded genomic instructions and self-organizing physical mechanisms to embryonic development. Read More

Genomics An immensely complex molecular network of interactions forms the foundation of human biology and disease. Genomic approaches provide a particularly illuminating window to biological systems, and when combined with advanced analysis allow us to learn and model this complexity. Read More

Neuroscience Our goal is to understand how the brain analyzes large and complex datasets streamed by sensory organs in order to aid efforts at building artificial neural systems and treating mental illness. Read More

Systems Biology At the Systems Biology group, we are developing new methods to learn the networks that run life’s program. Read More

News & Announcements

June 29, 2020

Plasticity May Make Neurons Vulnerable to Alzheimer’s Disease By Thomas Sumner

March 05, 2020

Geneticists Pump the Brakes on DNA, Revealing Key Developmental Process (Princeton University)

December 03, 2019

Unexpected Forces Cause Rotor Proteins to Self-Organize By Susan Reslewic Keatley

Upcoming Events

July 2020

13 Mon
- Meeting 10:00 AM - 12:00 PM
  Biophysical Modeling Group Meeting
14 Tue
- Meeting 1:00 - 2:00 PM
  Developmental Dynamics Group Meeting
- Lecture 1:15 - 2:30 PM
  Brown Bag Seminar
  
  Vikram K. Mulligan, Ph.D.Research Scientist, Systems Biology, CCB, Flatiron Institute
16 Thu
- Meeting 1:00 - 2:00 PM
  Genomic Group Meeting
20 Mon
- Meeting 10:00 AM - 12:00 PM
  Biophysical Modeling Group Meeting
21 Tue
- Meeting 1:00 - 2:00 PM
  Developmental Dynamics Group Meeting
23 Thu
- Meeting 1:00 - 2:00 PM
  Genomic Group Meeting
27 Mon
- Meeting 10:00 AM - 12:00 PM
  Biophysical Modeling Group Meeting
28 Tue
- Meeting 1:00 - 2:00 PM
  Developmental Dynamics Group Meeting
- Lecture 1:15 - 2:30 PM
  Brown Bag Seminar
  
  Christopher Park, Ph.D.Research Scientist, Genomics, Flatiron Institute

Research Highlights

May 14, 2020

Microtubule re-organization during female meiosis in C. elegans

Ina Lantzsch, Che-Hang Yu, Hossein Yazdkhasti, Norbert Lindow, Erik Szentgyörgyi, Steffen Prohaska, Martin Srayko, S. Fürthauer, Stefanie Redmann

The female meiotic spindles of most animals are acentrosomal and undergo drastic morphological changes while transitioning from metaphase to anaphase.…

https://www.biorxiv.org/content/10.1101/2020.05.14.095984v1

November 1, 2019

Lattices of Hydrodynamically Interacting Flapping Swimmers

A. U. Oza, L. Ristroph, M. Shelley

Fish schools and bird flocks exhibit complex collective dynamics whose self-organization principles are largely unknown. The influence of hydrodynamics on…

Physical Review X

October 25, 2019

Relating Rheotaxis and Hydrodynamic Actuation using Asymmetric Gold-Platinum Phoretic Rods

Q. Brosseau, F. Balboa Usabiaga, E. Lushi, Y. Wu, L. Ristroph, J. Zhang, M. Ward, M. Shelley

We explore the behavior of micron-scale autophoretic Janus (Au / Pt) rods, having various Au / Pt length ratios, swimming…

Physical Review Letters

Director

Michael Shelley, Ph.D.

Director, CCB

Michael Shelley joined the Simons Foundation in 2016 to work on the modeling and simulation of complex systems arising in physics and biology.

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