The biophysical modeling group focuses on the modeling and simulation of complex systems that arise in biology and soft condensed matter physics. This includes the dynamics of complex and active materials, and aspects of collective behavior and self-assembly in both natural systems (e.g., inside the cell) and synthetic ones. Our approach is based on mathematical modeling and analysis, the development and application of software tools for large-scale biophysical simulation, and close collaboration with experimentalists.

#### Group Leader

Michael Shelley joined the Simons Foundation in 2016 to work on the modeling and simulation of complex systems arising in physics and biology. He is an applied mathematician who co-founded and co-directs the Courant Institute’s Applied Mathematics Laboratory at New York University. Shelley joined the Courant Institute in 1992 and is the Lilian and George Lyttle Professor of Applied Mathematics. He holds a B.A. in mathematics from the University of Colorado and a Ph.D. in applied mathematics from the University of Arizona. He was a postdoctoral researcher at Princeton University and a member of the mathematics faculty at the University of Chicago before joining NYU. Shelley has received the François Frenkiel Award from the American Physical Society and the Julian Cole Lectureship from the Society for Industrial and Applied Mathematics, and he is a fellow of both societies.

Email Michael Shelley mshelley(replace this with the @ sign)simonsfoundation.org.

#### Publications

- Fast accurate methods for simulating fiber suspensions applied to cellular mechanics. E. Nazockdast, A. Rahimian, D. Needleman, and M. Shelley. Journal of Computational Physics (2016)
- The effect of microtubule-cytoplasm interactions on pronuclear migration. E. Nazockdast, A. Rahimian, D. Zorin, and M. Shelley submitted (2016)
- Forces positioning the mitotic spindle in the cell; Theories, and now experiments. H. Wu, E. Nazockdast, M. Shelley, and D. Needleman. To appear, Bioessays (2016)
- The dynamics of microtubule/motor-protein assemblies in biology and physics. M. Shelley. Annual Reviews of Fluid Mechanics 48, 487-506 (2016)
- Active contraction of microtubule networks. P. Foster, S. Furthauer, M. J. Shelley, and D. J. Needleman. eLife, 4:e10837 (2015)
- More publications here.

#### People

- Sebastian Fuerthauer, sfuerthauer(replace this with the @ sign)simonsfoundation.org
- Ehsan Nazockdast, enazockdast(replace this with the @ sign)simonsfoundation.org
- Naomi Oppenheimer, noppenheimer(replace this with the @ sign)simonsfoundation.org
- David Stein, dstein(replace this with the @ sign)simonsfoundation.org
- Wen Yan, wyan(replace this with the @ sign)simonsfoundation.org
- All bios

#### Open Positions

Research Fellow position: We are looking for a highly motivated individual with a strong background in one or more of the following fields: biophysics, applied mathematics, computational physics, or engineering (biological, mechanical, or chemical). The candidate will develop mathematical models and algorithms for understanding basic phenomena in complex fluids, active matter, cellular biophysics, and fluid-structure interactions. The candidate is expected to collaborate with other members of the Center for Computational Biology at the Flatiron Institute and with experimental physicists and biophysicists. The candidate will report to the group leader for biophysical modeling. This position will be based at the Flatiron Institute.

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