Abstract graphic of a grainy, light-colored, interlocking wave pattern centered on a dark blue background.

Galileo Galilei famously wrote that the universe is a book “written in the language of mathematics,” and that without it, “one wanders about in vain through a dark labyrinth.”

At the Simons Foundation, this enduring truth — that mathematics is the means by which we understand our world — shapes how we approach discovery across disciplines, from evolutionary ecology to theoretical physics.

We’re pleased to present this special edition of our annual report, which explores the centrality of mathematics in our work through stories on Möbius strips, string theory, machine learning, autism and more.

David N. Spergel, Ph.D.
President

Letters

2025 Letter From the President

Simons Foundation President David Spergel writes about the importance of mathematics, the changing AI landscape and why the next decade of science will look radically different from the last.

2025 Letter From the Chair

Simons Foundation Chair Marilyn Simons reflects on the two-way street between math and science, the power of collaboration and how sharing ideas across fields drives unexpected discoveries.