Two quantum particles can be intimately connected even when they are far apart, forming patterns beyond the scope of classical physics. When vast numbers of them link up, the outcome seems beyond comprehension altogether. The pattern-matching power of neural networks may be the key.

Leveraging personalized genomics can aid the development of effective autism therapies, promising new research suggests.

AI can recognize faces, drive cars and simulate the universe, but precisely how it works remains unknown. Flatiron Institute scientists plan to solve the mystery.

The 160-year-old Riemann hypothesis has deep connections to the distribution of prime numbers and remains one of the most important unsolved problems in mathematics.

David Hilbert put forth 23 problems that helped set the research agenda for mathematics in the 20th century. Here is a status report on those challenges.

Genetic dark matter makes up 98 percent of our genomes, yet scientists are still figuring out how it works.

Time began at the Big Bang — or did it? Alternative ideas, including a universe that repeatedly reboots itself, suggest something came before the Big Bang.

Despite numerous breakthroughs into the causes of autism, many mysteries about the condition remain.

Solving the mysteries of the brain requires reverse engineering the rules and patterns that control it.

Individual neurons and regions of the brain can encode surprisingly strange combinations of information.

How the Simonses developed their own algorithm for excellence in science philanthropy.

The director of the Simons Observatory describes the origin of the observatory, which aims to explain the origin of the universe.

To speed discovery, SFARI decided to break the traditional approach in which each laboratory collects its own datasets and keeps them close to the vest.

Seven general criteria and considerations are top of mind when we decide on collaborations to support.

By bringing researchers together to focus on specific scientific goals, we hope to accelerate the pace of discovery.

The institute has grown from a beautiful proposal into a bustling hub for computational science in astrophysics, biology, mathematics and quantum physics.

Why upgrading your computer every two years no longer makes sense.

We asked the foundation's distinguished scientist, who joined us in 2006 to lead the Simons Foundation Autism Research Initiative (SFARI), to reflect on the initiative and its accomplishments.

The push to gain a deep understanding of the genetics and neurobiology of autism has forced scientists to reexamine three ideas about the condition.

When it comes to the composition of the universe, we’ve made significant progress in finding out how little we know.

Describing many-body quantum systems is generally next to impossible, physicists thought — until they realized that localized entanglement holds the key.

Rocky planets inside, gas giants outside — we thought our solar system was typical. But the discovery of worlds around other stars has altered that view.

With its aesthetic appeal, symmetry has been a beacon for mathematicians and physicists.

Cerebral fascinations: We asked our neuroscientists why they find the brain beautiful.

The finely tuned collection of bacteria, archaea and fungi collectively known as the microbiome hold an exquisite power that we are only beginning to recognize.

The president of the Simons Foundation describes the growth of the organization and the evolution of its culture.

The chair of the Simons Foundation describes his five principles for building a successful organization.

Commemorating 25 years of advancing the frontiers of research in mathematics and the basic sciences

Even the most abstract mathematics or science is surprisingly useful. But should we be surprised by that?

Roger Bacon’s ‘three dignities’ illustrate not only how experimentation verifies and disproves theories but also how it produces new knowledge, even in mathematics.